当代医药论丛
噹代醫藥論叢
당대의약론총
Contemporary Medicine Forum
2015年
6期
12-14
,共3页
他汀类药物%糖代谢%影响%研究进展
他汀類藥物%糖代謝%影響%研究進展
타정류약물%당대사%영향%연구진전
key word] statins%glycometabolism%effect%research progress
他汀类药物是一种羟甲戊二酰辅酶A（HMG-CoA）还原酶抑制剂，具有降低血浆中胆固醇水平的作用。现代药理研究发现，他汀类药物除了具有降血脂的作用外，还对机体的糖代谢有一定的影响。本文首先介绍他汀类药物的种类（天然类和全合成类）及不同种类他汀类药物对机体糖代谢的影响，然后介绍他汀类药物引起糖代谢异常的作用机制，最后阐述他汀类药物在影响糖代谢的过程中所起到的积极作用及应用前景。
他汀類藥物是一種羥甲戊二酰輔酶A（HMG-CoA）還原酶抑製劑，具有降低血漿中膽固醇水平的作用。現代藥理研究髮現，他汀類藥物除瞭具有降血脂的作用外，還對機體的糖代謝有一定的影響。本文首先介紹他汀類藥物的種類（天然類和全閤成類）及不同種類他汀類藥物對機體糖代謝的影響，然後介紹他汀類藥物引起糖代謝異常的作用機製，最後闡述他汀類藥物在影響糖代謝的過程中所起到的積極作用及應用前景。
타정류약물시일충간갑무이선보매A（HMG-CoA）환원매억제제，구유강저혈장중담고순수평적작용。현대약리연구발현，타정류약물제료구유강혈지적작용외，환대궤체적당대사유일정적영향。본문수선개소타정류약물적충류（천연류화전합성류）급불동충류타정류약물대궤체당대사적영향，연후개소타정류약물인기당대사이상적작용궤제，최후천술타정류약물재영향당대사적과정중소기도적적겁작용급응용전경。
Statins has the significantly effect of decreasing cholesterol in plasma as a hydroxymethyl glutaryl coenzyme A (HMG-CoA) reductase inhibitor, but modern research has found that statins also have certain effect on glucose metabolism. This paper first introduces the types of statins and different influence on glucose metabolism, statins are divided into natural and total synthesis of class, then introducing the related mechanism that statins cause abnormal glucose metabolism ,its mechanism are related with its structure and the physicochemical properties, thus causing confuse of glucose uptake insulin secretion and isoprenoid and coenzyme Q10 synthesis disorders of glucose metabolism disorder. Finally talk about the positive role that statins plays in affecting glucose metabolism and its application prospects.
