CAJ | 학술논문

主动吸烟和被动吸烟引起呼吸道损伤，诱发多种疾病，包括气流受限为特征的慢性气道炎症疾病 COPD 和哮喘。香烟烟雾暴露引起气道炎症细胞浸润和炎症介质释放，气道高反应性，加重过敏性气道炎症。近年来国内外学者研究了小鼠暴露于香烟烟雾后 BALF 和肺组织中炎症细胞聚集和炎症介质释放和表达，使已致敏小鼠气道炎症加重，并探索了对于香烟烟雾诱导气道炎症的治疗新靶点。单核基因多态性与成人肺功能相关联，研究发现了香烟烟雾暴露与肺功能的相互作用。核转录因子κB激活酶2抑制剂/核转录因子κB 信号传导通路在香烟烟雾暴露诱导的炎症反应中并不重要，并且可能与COPD 发病无关。
주동흡연화피동흡연인기호흡도손상，유발다충질병，포괄기류수한위특정적만성기도염증질병 COPD 화효천。향연연무폭로인기기도염증세포침윤화염증개질석방，기도고반응성，가중과민성기도염증。근년래국내외학자연구료소서폭로우향연연무후 BALF 화폐조직중염증세포취집화염증개질석방화표체，사이치민소서기도염증가중，병탐색료대우향연연무유도기도염증적치료신파점。단핵기인다태성여성인폐공능상관련，연구발현료향연연무폭로여폐공능적상호작용。핵전록인자κB격활매2억제제/핵전록인자κB 신호전도통로재향연연무폭로유도적염증반응중병불중요，병차가능여COPD 발병무관。
Active smoking and passive smoking cause airway damage,induce many diseases, including two chronic inflammatory disorders of the airway characterized by airflow limitation,chronic obstructive pulmonary disease and asthma.In recent years,studies in mice have shown that cigarette smoke exposure can induce inflammatory cells gathered in airway and lead to inflammatory mediators release,cause airway hyperresponsiveness and enhance allergic airway inflammation.Single nucleotide polymorphism is associated with adult lung function.Inhibitor of nuclear factor-κB kinase-2/nuclear factor-κB signalling pathway does not play a prominent role in the inflammatory response to cigarette smoke exposure,and this pathway may not be important in the pathogenesis of chronic obstructive pulmonary disease.