中华神经科杂志
中華神經科雜誌
중화신경과잡지
Chinese Journal of Neurology
2015年
3期
169-174
,共6页
遇涛%张国君%胡振红%李小俚%王玉平%任志伟%朴媛媛%李勇杰
遇濤%張國君%鬍振紅%李小俚%王玉平%任誌偉%樸媛媛%李勇傑
우도%장국군%호진홍%리소리%왕옥평%임지위%박원원%리용걸
癫痫%语言%大脑皮质%脑电描记术
癲癇%語言%大腦皮質%腦電描記術
전간%어언%대뇌피질%뇌전묘기술
Epilepsy%Language%Cerebral cortex%Electroencephalography
目的 采用基于高频γ活动分析的语言功能皮质定位方法,为难治性癫痫患者实现个体化语言功能定位.方法 2012年10月至2014年2月选取因定位癫痫灶和语言功能区的需要,埋置了皮质电极的难治性癫痫患者8例,采集完成特定的听觉语言任务时的高频脑电活动,进行自适应定向传递函数(adaptive directed transfer function,ADTF)分析,并与皮质电刺激结果进行比较.结果 在患者完成听觉语言任务时的不同时间段,可以在相应的皮质区记录到高频γ活动;应用ADTF方法可以进一步估算皮质的功能连接模式.8例患者中,计数ADTF分析所定位的阳性功能位点111个,其中位于额叶及中央区的76个,位于颞叶35个;应用皮质电刺激方法,确定语言阳性结果7例,共22个位点,其中位于额叶的19个,位于颞叶的3个.去除1例未放置颞叶皮质电极患者的数值,ADTF分析法与皮质电刺激技术确定的阳性位点之比为:额叶60∶17,颞叶35∶3(x2 =3.563,P=0.059).结论 基于高频γ活动分析的语言功能定位方法具有较高的敏感度和耐受性,有可能成为定位癫痫患者语言功能皮质及相关网络的临床新方法.
目的 採用基于高頻γ活動分析的語言功能皮質定位方法,為難治性癲癇患者實現箇體化語言功能定位.方法 2012年10月至2014年2月選取因定位癲癇竈和語言功能區的需要,埋置瞭皮質電極的難治性癲癇患者8例,採集完成特定的聽覺語言任務時的高頻腦電活動,進行自適應定嚮傳遞函數(adaptive directed transfer function,ADTF)分析,併與皮質電刺激結果進行比較.結果 在患者完成聽覺語言任務時的不同時間段,可以在相應的皮質區記錄到高頻γ活動;應用ADTF方法可以進一步估算皮質的功能連接模式.8例患者中,計數ADTF分析所定位的暘性功能位點111箇,其中位于額葉及中央區的76箇,位于顳葉35箇;應用皮質電刺激方法,確定語言暘性結果7例,共22箇位點,其中位于額葉的19箇,位于顳葉的3箇.去除1例未放置顳葉皮質電極患者的數值,ADTF分析法與皮質電刺激技術確定的暘性位點之比為:額葉60∶17,顳葉35∶3(x2 =3.563,P=0.059).結論 基于高頻γ活動分析的語言功能定位方法具有較高的敏感度和耐受性,有可能成為定位癲癇患者語言功能皮質及相關網絡的臨床新方法.
목적 채용기우고빈γ활동분석적어언공능피질정위방법,위난치성전간환자실현개체화어언공능정위.방법 2012년10월지2014년2월선취인정위전간조화어언공능구적수요,매치료피질전겁적난치성전간환자8례,채집완성특정적은각어언임무시적고빈뇌전활동,진행자괄응정향전체함수(adaptive directed transfer function,ADTF)분석,병여피질전자격결과진행비교.결과 재환자완성은각어언임무시적불동시간단,가이재상응적피질구기록도고빈γ활동;응용ADTF방법가이진일보고산피질적공능련접모식.8례환자중,계수ADTF분석소정위적양성공능위점111개,기중위우액협급중앙구적76개,위우섭협35개;응용피질전자격방법,학정어언양성결과7례,공22개위점,기중위우액협적19개,위우섭협적3개.거제1례미방치섭협피질전겁환자적수치,ADTF분석법여피질전자격기술학정적양성위점지비위:액협60∶17,섭협35∶3(x2 =3.563,P=0.059).결론 기우고빈γ활동분석적어언공능정위방법구유교고적민감도화내수성,유가능성위정위전간환자어언공능피질급상관망락적림상신방법.
Objective To localize the functional language area based on high gamma activity recorded from electrocorticography for patients with refractory epilepsy.Methods Electrocorticographic signals were recorded during an auditory-language task for 8 patients with refractory epilepsy who underwent intracranial recording to localize the epileptogenic zone and language area from October 2012 to February 2014.The high gamma activities were analyzed with event-related synchronization and adaptive directed transfer function (ADTF).The results were compared to that of electoral cortical stimulation (ECS).Results The ADTF analysis for auditory-language task provided dynamic information about the connectivity pattern of cortical interaction.The temporal lobe produced the predominant event-related information outflow during listening period,and inferior frontal lobe produced the predominant event-related information outflow during answering period.A total of 111 cortical sites were identified as the predominant sites in the eventrelated information outflow according to the ADTF analysis,and 76 of the sites lied in frontal or central area,35 lied in temporal area.Twenty-two cortical sites were identified as language related sites according to electric cortical stimulation in 7 of the 8 patients,and 19 sites lied in frontal area,3 lied in temporal area.Excluding the number of one patient without electrodes covering temporal area,the positive numbers of ADTF analysis and ECS were 60 vs 17 in frontal area and 35 vs 3 in temporal area (x2 =3.563,P =0.059).The process of recording electrocorticographic signals for this method was quick and safe.Conclusion This method based on analysis of high gamma activity may be a useful complement to traditional electrocortical stimulation in the localization of language area for patients with refractory epilepsy.
