北京生物医学工程
北京生物醫學工程
북경생물의학공정
BEIJING BIOMEDICAL ENGINEERING
2015年
2期
156-160,207
,共6页
电刺激%无髓神经%传导阻断%阻断阈%恢复时间
電刺激%無髓神經%傳導阻斷%阻斷閾%恢複時間
전자격%무수신경%전도조단%조단역%회복시간
electrical stimulation%unmyelinated nerve%conduction block%block threshold%recovery time
目的：神经纤维异常兴奋会造成许多功能障碍疾病，因此，研究无髓神经纤维受到电刺激时动作电位的传播规律及传导阻断情况有重要的科研意义和临床价值。方法本文基于 Hodgkin-Huxley模型，在高频双向电刺激下研究无髓神经纤维的阻断阈和阻断机制，并提出一种电刺激结束后轴突恢复初始状态的时间测量方法。结果电刺激下直径大的神经纤维先被阻断，直径小的神经纤维后被阻断，并随着刺激频率的增加，阻断阈在12~16 kHz时达到峰值。阻断电极处钠离子和钾离子通道的持续开放造成神经纤维的传导阻断。电刺激结束后，神经纤维恢复初始状态的时间随着频率的增加而增加。结论本研究揭示了无髓神经纤维的阻断机制以及电刺激结束后神经纤维恢复初始状态的时间与电刺激频率的关系，这些结果将为相关动物实验和功能电刺激的临床应用提供更多的信息。
目的：神經纖維異常興奮會造成許多功能障礙疾病，因此，研究無髓神經纖維受到電刺激時動作電位的傳播規律及傳導阻斷情況有重要的科研意義和臨床價值。方法本文基于 Hodgkin-Huxley模型，在高頻雙嚮電刺激下研究無髓神經纖維的阻斷閾和阻斷機製，併提齣一種電刺激結束後軸突恢複初始狀態的時間測量方法。結果電刺激下直徑大的神經纖維先被阻斷，直徑小的神經纖維後被阻斷，併隨著刺激頻率的增加，阻斷閾在12~16 kHz時達到峰值。阻斷電極處鈉離子和鉀離子通道的持續開放造成神經纖維的傳導阻斷。電刺激結束後，神經纖維恢複初始狀態的時間隨著頻率的增加而增加。結論本研究揭示瞭無髓神經纖維的阻斷機製以及電刺激結束後神經纖維恢複初始狀態的時間與電刺激頻率的關繫，這些結果將為相關動物實驗和功能電刺激的臨床應用提供更多的信息。
목적：신경섬유이상흥강회조성허다공능장애질병，인차，연구무수신경섬유수도전자격시동작전위적전파규률급전도조단정황유중요적과연의의화림상개치。방법본문기우 Hodgkin-Huxley모형，재고빈쌍향전자격하연구무수신경섬유적조단역화조단궤제，병제출일충전자격결속후축돌회복초시상태적시간측량방법。결과전자격하직경대적신경섬유선피조단，직경소적신경섬유후피조단，병수착자격빈솔적증가，조단역재12~16 kHz시체도봉치。조단전겁처납리자화갑리자통도적지속개방조성신경섬유적전도조단。전자격결속후，신경섬유회복초시상태적시간수착빈솔적증가이증가。결론본연구게시료무수신경섬유적조단궤제이급전자격결속후신경섬유회복초시상태적시간여전자격빈솔적관계，저사결과장위상관동물실험화공능전자격적림상응용제공경다적신식。
Objective Abnormal nerve fiber activation can cause many disorder diseases. Therefore, the study on action potential propagation and conduction block of unmyelinated nerve with electrical stimulation has great values for science research and clinical application. Methods Based on Hodgkin-Huxley model,we research on fiber blocking threshold and blocking mechanism of unmyelinated nerve under high frequency biphasic electrical stimulation. A measurement method for the recovery time of axon to the initial state after electrical stimulation is proposed in this paper. Results Larger diameter fibers tend to be blocked early than smaller nerve fibers under electrical stimulation. With the increase of frequency,the biggest block threshold is 12 kHz to 16 kHz. The high frequency stimulation produces constant activation of both sodium and potassium channels at the nerve fiber node under the block electrode,which causes the conduction block of nerve fiber. After the electrical stimulation,the recovery time of nerve fiber to the initial state increases with the increase of frequency. Conclusions This study reveals the blocking mechanism of unmyelinated nerve fiber,and the relationship between recovery time of axon to the initial state and the frequency of electrical stimulation after electrical stimulation. The results can provide more information for animal experiments and clinical applications.
