CAJ | 학술논문

Kruppel样转录因子8（KLF8）是KLFs家族中的一员，其在羧基端含有3个保守的C2H2锌指结构及氨基端可变的转录调节结构Ⅱ，转录调节结构Ⅱ含PVALS/T基序，在氨基端和羧基端内存在核定位序。 KLF8在细胞侵袭和上皮-间质转化、细胞周期循环、细胞致癌性转化及各种肿瘤（肝癌、口腔癌、卵巢癌、胃癌）发生发展中发挥重要作用。
Kruppel양전록인자8（KLF8）시KLFs가족중적일원，기재최기단함유3개보수적C2H2자지결구급안기단가변적전록조절결구Ⅱ，전록조절결구Ⅱ함PVALS/T기서，재안기단화최기단내존재핵정위서。 KLF8재세포침습화상피-간질전화、세포주기순배、세포치암성전화급각충종류（간암、구강암、란소암、위암）발생발전중발휘중요작용。
Kruppel-like factor 8 (KLF8) is a member of Kruppel-like transcription factors (KLFs) family. It shares three well-conserved C2H2 zinc finger domalns on its C-terminus and variable transcriptional regulation domaln on its N-terminus. Its transcriptional regulation domaln has PVALS/T motif. Nuclear localization signal exists on C-terminus and N-terminus. KLF8 plays an important role on cell cycle, cell invasion, epithelial tomesenchymal transition, cellula oncogenic transformation and occurrence and development of variety of tumors (liver cancer, oral cancer, ovarian cancer and stomach cancer).