中国医药导报
中國醫藥導報
중국의약도보
CHINA MEDICAL HERALD
2015年
12期
133-136
,共4页
原发性高血压%抑郁症%舍曲林
原髮性高血壓%抑鬱癥%捨麯林
원발성고혈압%억욱증%사곡림
Essential hypertension%Depression%Setraline
目的：探讨使用舍曲林治疗原发性高血压伴抑郁患者的临床效果。方法选择2012年1月~2014年7月在煤炭总医院治疗的124例原发性高血压伴抑郁患者为研究对象，将其随机分为对照组（常规降压）和治疗组（常规降压+抗抑郁剂院舍曲林），随访8周后，对比两组治疗前后汉密尔顿抑郁量表（HAMD）得分、血压及睡眠情况。结果两组治疗前年龄、性别、收缩压、舒张压、HAMD、匹兹堡睡眠质量指数（PSQI）比较差异均无统计学意义（P>0.05）；治疗组治疗后收缩压、舒张压均低于治疗前及对照组，差异有统计学意义（P<0.05或P<0.01）；治疗组治疗后HAMD、PSQI均低于治疗前及对照组，差异有统计学意义（P<0.05或P<0.01）；对照组治疗前后HAMD、PSQI差异无统计学意义（P>0.05）。结论在高血压伴抑郁症患者中适当使用舍曲林可以起到辅助降压的作用，还可以控制抑郁情绪，改善睡眠质量，值得临床应用推广。
目的：探討使用捨麯林治療原髮性高血壓伴抑鬱患者的臨床效果。方法選擇2012年1月~2014年7月在煤炭總醫院治療的124例原髮性高血壓伴抑鬱患者為研究對象，將其隨機分為對照組（常規降壓）和治療組（常規降壓+抗抑鬱劑院捨麯林），隨訪8週後，對比兩組治療前後漢密爾頓抑鬱量錶（HAMD）得分、血壓及睡眠情況。結果兩組治療前年齡、性彆、收縮壓、舒張壓、HAMD、匹玆堡睡眠質量指數（PSQI）比較差異均無統計學意義（P>0.05）；治療組治療後收縮壓、舒張壓均低于治療前及對照組，差異有統計學意義（P<0.05或P<0.01）；治療組治療後HAMD、PSQI均低于治療前及對照組，差異有統計學意義（P<0.05或P<0.01）；對照組治療前後HAMD、PSQI差異無統計學意義（P>0.05）。結論在高血壓伴抑鬱癥患者中適噹使用捨麯林可以起到輔助降壓的作用，還可以控製抑鬱情緒，改善睡眠質量，值得臨床應用推廣。
목적：탐토사용사곡림치료원발성고혈압반억욱환자적림상효과。방법선택2012년1월~2014년7월재매탄총의원치료적124례원발성고혈압반억욱환자위연구대상，장기수궤분위대조조（상규강압）화치료조（상규강압+항억욱제원사곡림），수방8주후，대비량조치료전후한밀이돈억욱량표（HAMD）득분、혈압급수면정황。결과량조치료전년령、성별、수축압、서장압、HAMD、필자보수면질량지수（PSQI）비교차이균무통계학의의（P>0.05）；치료조치료후수축압、서장압균저우치료전급대조조，차이유통계학의의（P<0.05혹P<0.01）；치료조치료후HAMD、PSQI균저우치료전급대조조，차이유통계학의의（P<0.05혹P<0.01）；대조조치료전후HAMD、PSQI차이무통계학의의（P>0.05）。결론재고혈압반억욱증환자중괄당사용사곡림가이기도보조강압적작용，환가이공제억욱정서，개선수면질량，치득림상응용추엄。
Objective To investigate the application value of Setraline in essential hypertension patients with depres-sion. Methods 124 patients with essential hypertension and depression treated in Meitan General Hospital from January 2012 to July 2014 were chosen, they were randomly divided into treatment group and control group. The treatment group received routine antihypertensive and antidepressant drug:Setraline, while the control group received routine an-tihypertensive. After followed up for 8 weeks, the HAMD scores, blood pressure and sleep quality before and after treat-ment in the two groups were compared. Results The age, gender, systolic blood pressure, diastolic blood pressure HAMD and PSQI before treatment in the two group were compared, the differences were not statistically significant (P> 0.05). The systolic blood pressure, diastolic blood pressure after treatment in the treatment group were lower than before treatment and control group, the differences were statistically significant (P < 0.05 or P < 0.01); the HAMD, PSQI after treatment in the treatment group were lower than before treatment and control group, the differences were statistically significant (P< 0.05 or P< 0.01); HAMD and PSQI before and after treatment in the control group were compared, the differences were not statistically significant (P> 0.05). Conclusion The application of Setraline in es-sential hypertension patients with depression has effect on antihypertensive therapy, it can decrease depression and im-prove sleep quality, it is worthy of clinical application and promotion.
