CAJ | 학술논문

毒性分子-抗毒性分子系统（ toxin-antitoxin systems，TA systems）被发现广泛存在于细菌染色体、质粒以及古细菌基因组中。TA系统是由2个基因组成的操纵子，这2个基因分别编码稳定的毒性分子和不稳定的抗毒性分子。毒性分子总是蛋白质，抗毒性分子可能是蛋白质或RNA。因此，根据抗毒性分子的性质和作用方式的不同可将TA系统家族分为5种类型。Ⅰ型和Ⅲ型的抗毒性分子是RNA，能抑制毒性分子的合成或者与其隔离；II、IV和V型的抗毒性分子是蛋白质，能隔离、平衡毒性分子作用或抑制其合成。TA系统具有多种生物学功能。目前研究表明，TA系统可能在细菌应激应答、程序化细胞死亡、多重耐药的形成、防止DNA入侵、稳定大基因组片段等方面有重要的作用。
독성분자-항독성분자계통（ toxin-antitoxin systems，TA systems）피발현엄범존재우세균염색체、질립이급고세균기인조중。TA계통시유2개기인조성적조종자，저2개기인분별편마은정적독성분자화불은정적항독성분자。독성분자총시단백질，항독성분자가능시단백질혹RNA。인차，근거항독성분자적성질화작용방식적불동가장TA계통가족분위5충류형。Ⅰ형화Ⅲ형적항독성분자시RNA，능억제독성분자적합성혹자여기격리；II、IV화V형적항독성분자시단백질，능격리、평형독성분자작용혹억제기합성。TA계통구유다충생물학공능。목전연구표명，TA계통가능재세균응격응답、정서화세포사망、다중내약적형성、방지DNA입침、은정대기인조편단등방면유중요적작용。
Toxin-antitoxin systems( TA systems)extensively exist in bacterial chromosomes and plasmids as well as in archaic genomes. TA systems is an operon consisting of two genes,they are respectively toxin molecule of stably encoded and anti-toxin molecule of unstably encoded. Toxin molecule is always protein,while antitoxin molecule may be protein or RNA. Therefore,currently TA systems family can be divided into five different types. Antitoxin molecule of type I and type III is RNA,it can inhibit the synthesis of toxin molecule or isolate toxin molecule. Antitoxin mole-cule of type II,IV,and V is protein,it can isolate,balance the role of toxin molecule or inhibit its synthesis. TA systems possess multiple biological functions. Recent studies suggested that TA systems might play important role and have involved in the cell stress response,programmed cell death,the form of multidrug resistance,prevention from DNA invasion,as well as stabilization of large genomic fragments and other aspects.