CAJ | 학술논문

抗癌晶体蛋白（ parasporins，PS）是由没有杀虫活性的苏云金芽胞杆菌产生的一种晶体蛋白，在经过蛋白酶酶解后产生的活性多肽对来自人类不同组织的癌细胞具有特异性细胞毒性，而对正常细胞具有较低毒性或不具有毒性，是一种具有很大潜力的微生物抗癌蛋白。就最近几年苏云金芽胞杆菌中已发现的抗癌晶体蛋白的种类、结构特征、细胞活性谱和杀虫机制进行简要概述。
항암정체단백（ parasporins，PS）시유몰유살충활성적소운금아포간균산생적일충정체단백，재경과단백매매해후산생적활성다태대래자인류불동조직적암세포구유특이성세포독성，이대정상세포구유교저독성혹불구유독성，시일충구유흔대잠력적미생물항암단백。취최근궤년소운금아포간균중이발현적항암정체단백적충류、결구특정、세포활성보화살충궤제진행간요개술。
Parasporin( PS)is a kind of crystal proteins synthesized by Bacillus thuringiensis that has no insecticidal activity,after digested by protease the zymolytically active polypeptide possessed specific cytotoxicity against human cancer cells from diferent tissues,however,having lower or non toxicity against normal cells;it is a kind of microbial anti-cancer protein with great potency. Category of the PSs that have been discovered in B. thuringiensis in recent years,their structural features,cytoactive spectrum,and insectcidal mechanism were briefly summarized in this paper.