CAJ | 학술논문

目的：观察体腔循环灌注热化疗治疗晚期肿瘤合并腹腔积液的疗效和安全性。方法随机抽样选取122例经组织病理学或细胞学检查确诊晚期肿瘤伴恶性腹腔积液患者作为研究对象，分别接受体腔循环灌注热化疗及腹腔灌注化疗。观察两组患者的疗效、不良反应及生存时间。结果体腔循环灌注热化疗组与腹腔灌注化疗组的腹腔积液有效率分别为81.1%、55.6%，疾病控制率分别为94.9%、77.8%。两组差异有统计学意义（P＜0.05）。两组患者中位PFS分别为6.6、5.4个月，有统计学意义（P＜0.001），中位OS分别为15、13个月，无统计学意义（P＞0.05）；两组不良反应对照无差异（P＞0.05）。结论体腔循环灌注热化疗能明显提高晚期肿瘤恶性腹腔积液的近期控制率，疗效显著，不良反应轻。
목적：관찰체강순배관주열화료치료만기종류합병복강적액적료효화안전성。방법수궤추양선취122례경조직병이학혹세포학검사학진만기종류반악성복강적액환자작위연구대상，분별접수체강순배관주열화료급복강관주화료。관찰량조환자적료효、불량반응급생존시간。결과체강순배관주열화료조여복강관주화료조적복강적액유효솔분별위81.1%、55.6%，질병공제솔분별위94.9%、77.8%。량조차이유통계학의의（P＜0.05）。량조환자중위PFS분별위6.6、5.4개월，유통계학의의（P＜0.001），중위OS분별위15、13개월，무통계학의의（P＞0.05）；량조불량반응대조무차이（P＞0.05）。결론체강순배관주열화료능명현제고만기종류악성복강적액적근기공제솔，료효현저，불량반응경。
ObjectiveTo evaluate the effect and safety of body cavity perfusion hyperthermic chemotherapy in the treatment of malignant seroperitoneum. Methods 122 randomly selected patients of malignant seroperitoneum, which were diagnosed by histopathology or cytology, were treated by body cavity perfusion hyperthermic chemotherapy and abdominal perfusion chemotherapy. The efifcacy, adverse reactions and survival time after both treatments were analyzed.Results Body cavity perfusion thermo-chemotherapy group and intraperitoneal chemotherapy for peritoneal effusion efifciency of 81.1% and 55.6%, disease control rate was 94.9% and 77.8%. The difference was statistically signiifcant(P<0.05). Two groups of patients median PFS was 6.6 months and 5.4 months, statistically significant(P<0.001), median OS was 15 months and 13 months, no significant difference(P>0.05); Two adverse reactions in control no difference(P>0.05).Conclusion Thermochemotherapy in systemic circulation showed higher short-term efficiency and better safety than abdominal perfusion chemotherapy in the treatment of malignant seroperitoneum.