福建医科大学学报
福建醫科大學學報
복건의과대학학보
JOURNAL OF FUJIAN MEDICAL UNIVERSITY
2015年
1期
40-43
,共4页
胃肿瘤%预后%前列腺素内过氧化物合酶类%肿瘤蛋白质类
胃腫瘤%預後%前列腺素內過氧化物閤酶類%腫瘤蛋白質類
위종류%예후%전렬선소내과양화물합매류%종류단백질류
stomach neoplasms%prognosis%prostaglandin-endoperoxide synthases%neoplasm pro-teins
目的：探讨Survivin在胃癌组织中表达情况以及对胃癌患者生存期的影响。方法采取免疫组织化学方法检测Survivin在胃癌组织的表达情况，根据Survivin是否表达将103例胃癌患者分成Survivin阳性表达组和阴性表达组，使用Kaplan‐M eier生存分析法评估2组患者的生存率，并采用Cox模型多因素分析胃癌患者死亡的影响因素。结果 Survivin在胃癌组织中表达阳性率为71．8％，2组患者在胃癌的临床分期（χ2＝6．434）、分化程度（χ2＝13．026）、淋巴结是否转移（χ2＝5．543）等方面差别有统计学意义（均为 P＜0．05）。Kaplan‐Meier生存分析表明，Survivin阳性表达组中位生存期为22月，而阴性表达组为40月。Log‐rank检验提示，两条生存曲线差别有统计学意义，Survivin阳性表达组胃癌患者生存率明显低于阴性表达组（χ2＝15．69，P＜0．001）；Cox多因素分析显示，调整了年龄、性别、肿瘤分期、分化程度、治疗方式等因素后，Survivin阳性表达组患者死亡风险增加（HR＝2．651，95％ CI 1．434～4．900，P＝0．002）。结论 Survivin表达与胃癌患者的生存时间密切相关，是影响胃癌患者生存期的独立危险因素。
目的：探討Survivin在胃癌組織中錶達情況以及對胃癌患者生存期的影響。方法採取免疫組織化學方法檢測Survivin在胃癌組織的錶達情況，根據Survivin是否錶達將103例胃癌患者分成Survivin暘性錶達組和陰性錶達組，使用Kaplan‐M eier生存分析法評估2組患者的生存率，併採用Cox模型多因素分析胃癌患者死亡的影響因素。結果 Survivin在胃癌組織中錶達暘性率為71．8％，2組患者在胃癌的臨床分期（χ2＝6．434）、分化程度（χ2＝13．026）、淋巴結是否轉移（χ2＝5．543）等方麵差彆有統計學意義（均為 P＜0．05）。Kaplan‐Meier生存分析錶明，Survivin暘性錶達組中位生存期為22月，而陰性錶達組為40月。Log‐rank檢驗提示，兩條生存麯線差彆有統計學意義，Survivin暘性錶達組胃癌患者生存率明顯低于陰性錶達組（χ2＝15．69，P＜0．001）；Cox多因素分析顯示，調整瞭年齡、性彆、腫瘤分期、分化程度、治療方式等因素後，Survivin暘性錶達組患者死亡風險增加（HR＝2．651，95％ CI 1．434～4．900，P＝0．002）。結論 Survivin錶達與胃癌患者的生存時間密切相關，是影響胃癌患者生存期的獨立危險因素。
목적：탐토Survivin재위암조직중표체정황이급대위암환자생존기적영향。방법채취면역조직화학방법검측Survivin재위암조직적표체정황，근거Survivin시부표체장103례위암환자분성Survivin양성표체조화음성표체조，사용Kaplan‐M eier생존분석법평고2조환자적생존솔，병채용Cox모형다인소분석위암환자사망적영향인소。결과 Survivin재위암조직중표체양성솔위71．8％，2조환자재위암적림상분기（χ2＝6．434）、분화정도（χ2＝13．026）、림파결시부전이（χ2＝5．543）등방면차별유통계학의의（균위 P＜0．05）。Kaplan‐Meier생존분석표명，Survivin양성표체조중위생존기위22월，이음성표체조위40월。Log‐rank검험제시，량조생존곡선차별유통계학의의，Survivin양성표체조위암환자생존솔명현저우음성표체조（χ2＝15．69，P＜0．001）；Cox다인소분석현시，조정료년령、성별、종류분기、분화정도、치료방식등인소후，Survivin양성표체조환자사망풍험증가（HR＝2．651，95％ CI 1．434～4．900，P＝0．002）。결론 Survivin표체여위암환자적생존시간밀절상관，시영향위암환자생존기적독립위험인소。
Objective To investigate the expression of Survivin in gastric carcinoma tissue and its effect on survival in patients with gastric cancer . Methods Immunohistochemical method was used to de‐tect the expression of Survivin in gastric carcinoma tissues . According to w hether Survivin in gastric car‐cinoma was expressed ,we divided the patients into two groups . The survival rate was analyzed with Ka‐plan‐Meier survival analysis ,and predictors analysis for the death of gastric carcinoma patients was per‐formed with Cox proportional hazards regression model . Results The positive expression rate of Sur‐vivin in gastric carcinoma tissues was 71 .8% . There were significant differences between the two groups (Survivin positive group vs Survivin negative group) in clinical TNM stage(χ2 =6 .434 ,P<0 .05) ,tissue differentiation(χ2 =13 .026 , P<0 .05)and lymphnode metastasis(χ2 =5 .543 , P<0 .05) . Kaplan‐Meier survival analysis demonstrated that median survival times for the Survivin positive expression group and negative expression group were 22 months and 40 months respectively . The Log‐rank test revealed that there wassignificant difference between the two survival curves ,and the survival rate of Survivin positive expression group was lower than the group with Survivin negatively expressed (χ2 =15 .69 ,P<0 .001) . Cox proportional hazards regression analysis indicated ,adjusted forage ,sex ,clinical TNM stage ,differen‐tiation and treatments , that the risk of mortality was increased in Survivin positive expression group (HR=2 .651 ,95% CI 1 .434~4 .900 ,P=0 .002) . Conclusion Survivin expressed in gastric carcinoma was closely correlated with the survival time of those patients ,It is an independent prognostic factor in pa‐tients of gastric carcinoma .
