滨州医学院学报
濱州醫學院學報
빈주의학원학보
JOURNAL OF BINZHOU MEDICAL COLLEGE
2015年
2期
101-102,151
,共3页
免疫细胞%原因不明反复流产%主动免疫治疗
免疫細胞%原因不明反複流產%主動免疫治療
면역세포%원인불명반복유산%주동면역치료
unexplained recurrent spontaneous abortion%active immunotherapy%immune cell
目的：探讨主动免疫治疗前后原因不明反复流产（URSA）患者免疫细胞表达水平的变化。方法选择 URSA 患者65例作为实验组，另选择30例健康未孕妇女作为对照组。采用丈夫淋巴细胞对 URSA 患者进行主动免疫治疗，分别于治疗前和治疗后2周采集患者外周血并检测其免疫细胞的标志，检测对照组外周血中免疫细胞的标志作为对照。结果治疗前， URSA 患者的 CD4＋细胞百分比、CD4∶ CD8比值和 NK 细胞百分比明显高于对照组（41.75±4.34vs36.04±3.85，1.75±0.65vs1.44±0.47，17.10±5.43vs9.87±4.76，P ＜0.05）；治疗后，三者均下降，治疗前后比较具有明显差异（41.75±4.34vs35.83±5.72，1.75±0.65vs1.41±0.51，17.10±5.43vs11.27±3.02，P＜0.05）。结论 URSA 患者的免疫系统处于活跃状态，T 细胞和 NK 细胞的变化可能与 URSA 的发生有关。淋巴细胞免疫治疗是治疗 URSA 的有效手段。
目的：探討主動免疫治療前後原因不明反複流產（URSA）患者免疫細胞錶達水平的變化。方法選擇 URSA 患者65例作為實驗組，另選擇30例健康未孕婦女作為對照組。採用丈伕淋巴細胞對 URSA 患者進行主動免疫治療，分彆于治療前和治療後2週採集患者外週血併檢測其免疫細胞的標誌，檢測對照組外週血中免疫細胞的標誌作為對照。結果治療前， URSA 患者的 CD4＋細胞百分比、CD4∶ CD8比值和 NK 細胞百分比明顯高于對照組（41.75±4.34vs36.04±3.85，1.75±0.65vs1.44±0.47，17.10±5.43vs9.87±4.76，P ＜0.05）；治療後，三者均下降，治療前後比較具有明顯差異（41.75±4.34vs35.83±5.72，1.75±0.65vs1.41±0.51，17.10±5.43vs11.27±3.02，P＜0.05）。結論 URSA 患者的免疫繫統處于活躍狀態，T 細胞和 NK 細胞的變化可能與 URSA 的髮生有關。淋巴細胞免疫治療是治療 URSA 的有效手段。
목적：탐토주동면역치료전후원인불명반복유산（URSA）환자면역세포표체수평적변화。방법선택 URSA 환자65례작위실험조，령선택30례건강미잉부녀작위대조조。채용장부림파세포대 URSA 환자진행주동면역치료，분별우치료전화치료후2주채집환자외주혈병검측기면역세포적표지，검측대조조외주혈중면역세포적표지작위대조。결과치료전， URSA 환자적 CD4＋세포백분비、CD4∶ CD8비치화 NK 세포백분비명현고우대조조（41.75±4.34vs36.04±3.85，1.75±0.65vs1.44±0.47，17.10±5.43vs9.87±4.76，P ＜0.05）；치료후，삼자균하강，치료전후비교구유명현차이（41.75±4.34vs35.83±5.72，1.75±0.65vs1.41±0.51，17.10±5.43vs11.27±3.02，P＜0.05）。결론 URSA 환자적면역계통처우활약상태，T 세포화 NK 세포적변화가능여 URSA 적발생유관。림파세포면역치료시치료 URSA 적유효수단。
Objective To investigate the change of immune cells before and after immunotherapy in patients with unexplained recurrent spontaneous abortion (URSA) .Methods 65 URSA patients and 30 normal nonpregnant women were enrolled into experiment group and control group respectively .URSA patients underwent immunotherapy using paternal lymphocytes .Pe‐ripheral blood from experiment group was collected and examined for markers of immune cells before and two weeks after im ‐munotherapy .Peripheral blood from control group was examined as control .Results Before the immunotherapy ,the proportion of CD4 + T cells ,the relative proportion of CD4 ∶ CD8 cell ratios and the relative proportion of natural killer (NK) cells were significantly higher in the URSA patient group than in the control group (41.75 ± 4.34vs36.04 ± 3.85 ,1.75 ± 0.65vs1.44 ± 0.47 ,17.10 ± 5.43vs9.87 ± 4.76 ,P< 0.05) .After the therapy ,all of these three measures were decreased and statistically sig ‐nificant differences before and after the immunotherapy were detected (41.75 ± 4.34vs35.83 ± 5.72 ,1.75 ± 0.65vs1.41 ± 0.51 , 17.10 ± 5.43vs11.27 ± 3.02 ,P< 0.05) .Conclusion The immune system appears to be activated in the URSA patients .The al‐terations in T and NK cells may be involved in the etiopathogenesis of URSA .Lymphocyte immunotherapy appears to be an ef‐fective treatment for URSA patients .
