CAJ | 학술논문

目的：利用屏气功能磁共振成像（fMRI）评价正常中老年人脑血管反应能力（CVR）的分布特征。方法对25名健康中老年人进行屏气任务的 fMRI 检测，采用统计参数图8（SPM8）进行数据处理，分析屏气引起的全脑血氧水平依赖（BOLD）信号的变化。分析大脑前动脉、大脑中动脉、大脑后动脉供血的皮层区和基底节区屏气BOLD 信号变化的差异。结果屏气引起的 BOLD 信号升高区域为广泛的皮层灰质和皮层下灰质核团。基底节区的 BOLD 信号变化百分比（PSC）最低（P ＜0．001），大脑后动脉供血区的 PSC 显著高于其他血管区（P ＜0．05）。结论屏气 fMRI 是一种可靠的、简便易行的 CVR 评价方法，正常中老年人基底节区 CVR 较低，而大脑后动脉供血区的 CVR 较高。
목적：이용병기공능자공진성상（fMRI）평개정상중노년인뇌혈관반응능력（CVR）적분포특정。방법대25명건강중노년인진행병기임무적 fMRI 검측，채용통계삼수도8（SPM8）진행수거처리，분석병기인기적전뇌혈양수평의뢰（BOLD）신호적변화。분석대뇌전동맥、대뇌중동맥、대뇌후동맥공혈적피층구화기저절구병기BOLD 신호변화적차이。결과병기인기적 BOLD 신호승고구역위엄범적피층회질화피층하회질핵단。기저절구적 BOLD 신호변화백분비（PSC）최저（P ＜0．001），대뇌후동맥공혈구적 PSC 현저고우기타혈관구（P ＜0．05）。결론병기 fMRI 시일충가고적、간편역행적 CVR 평개방법，정상중노년인기저절구 CVR 교저，이대뇌후동맥공혈구적 CVR 교고。
Objective To assess the distribution pattern of cerebrovascular reactivity (CVR)in healthy middle-aged or elderly people by using breath holding functional magnetic resonance imaging (fMRI).Methods Twenty-five middle-aged or elderly people were recruited and performed an fMRI with a breath holding task.Statistical parametric mapping 8 (SPM8)was applied in data processing to analyze the blood oxygen level dependent (BOLD)signal chan-ges induced by breath holding.Differences in signal changes during breath holding were detected among the cortical ter-ritory supplied by the anterior cerebral artery,middle cerebral artery,posterior cerebral artery and basal ganglia regions. Results Increased BOLD signal induced by breath holding widely distributed in gray matter cortices and subcortical gray matter nuclei.The lowest percentage of BOLD signal change (PSC)was detected in the basal ganglia regions (P <0.001),and the posterior cerebral artery regions showed the highest PSC (P <0.05).Conclusion Breath hold-ing fMRI is a convenient and reliable method for CVR assessing.Among healthy middle-aged or elderly people,the basal ganglia regions shows the lowest CVR while the PCA territory the highest.