CAJ | 학술논문

目的：高通量透析对肾性骨病患者血清成纤维细胞生长因子‐23（FGF‐23）及骨代谢的影响。方法将82例肾性骨病患者随机分为实验组（42例）和对照组（40例），治疗3个月后，对比观察治疗前后临床疗效、血清 Ca2＋、P3＋、甲状旁腺激素（PT H）及 FGF‐23水平的变化。结果①经过3个月的治疗，实验组患者肾性骨病的临床有效率显著高于对照组（P＜0.05），具有统计学意义；②高通量透析患者血清 Ca2＋及 PT H 水平未见明显变化，血清 P3＋水平虽然亦显著升高，但升高幅度未及对照组，具有统计学意义（P＜0.05），对照组患者血清 Ca2＋显著下降的同时，血 P3＋及 PT H 水平显著升高（P＜0.05）；③两组患者在治疗前血清 FGF‐23的表达无显著性差异（P＞0.05），但在治疗后，实验组血清 FGF‐23的水平较治疗前无显著性改变（P＞0.05），对照组较治疗前显著升高，同时其治疗后血清 FGF‐23的水平较实验组组亦显著性升高（P ＜0.05），具有统计学意义。结论高通量透析可以较好的改善肾性骨病患者的临床症状，较普通透析，可以更好的清除血清中 FGF‐23，对肾性骨病的发展具有一定的延缓作用。
목적：고통량투석대신성골병환자혈청성섬유세포생장인자‐23（FGF‐23）급골대사적영향。방법장82례신성골병환자수궤분위실험조（42례）화대조조（40례），치료3개월후，대비관찰치료전후림상료효、혈청 Ca2＋、P3＋、갑상방선격소（PT H）급 FGF‐23수평적변화。결과①경과3개월적치료，실험조환자신성골병적림상유효솔현저고우대조조（P＜0.05），구유통계학의의；②고통량투석환자혈청 Ca2＋급 PT H 수평미견명현변화，혈청 P3＋수평수연역현저승고，단승고폭도미급대조조，구유통계학의의（P＜0.05），대조조환자혈청 Ca2＋현저하강적동시，혈 P3＋급 PT H 수평현저승고（P＜0.05）；③량조환자재치료전혈청 FGF‐23적표체무현저성차이（P＞0.05），단재치료후，실험조혈청 FGF‐23적수평교치료전무현저성개변（P＞0.05），대조조교치료전현저승고，동시기치료후혈청 FGF‐23적수평교실험조조역현저성승고（P ＜0.05），구유통계학의의。결론고통량투석가이교호적개선신성골병환자적림상증상，교보통투석，가이경호적청제혈청중 FGF‐23，대신성골병적발전구유일정적연완작용。
Objective To investigate the effect of High flux dialysis on fibroblast growth factor‐23 and bone metabolismrenal in renal osteodystrophy patients .Methods 82 cases of renal osteodystrophy patients were randomly divided into treatment group (42 cases) and control group (40 cases) ,T He Ca2 + ,P3 + ,PT H and fibroblast growth factor‐23 (FGF‐23) were compared after 3 months treatment .Results ① The clinical effectiveness in experimental group is significantly higher than control group (P< 0.05) after 3 months treatment ;② The PT H and Ca2 + level in treatment group has no change ,the P3 + was significantly higher ,but the rise was lower than the control group (P< 0.05) ,the Ca2 + in control group was significantly lower ,and P3 + and PT H level was increased higher (p < 0 .05) ;③ The FGF‐23 was no significant difference between two groups before the treat‐ment (P> 0.05) ,however ,the FGF - 23 in experimental group was no significant change (P> 0.05) after 3months ,a signifi‐cant rise in the control group before the treatment ,and after the treatment the levels of serum FGF‐23 was also significantly in‐creased (P< 0.05) .Conclusion High flux dialysis can better improve the clinical symptoms on renal osteodystrophy patients , compared with ordinary dialysis ,it can better eliminate FGF - 23 in serum ,and has a certain extent in the bone metabolismre‐nal .