CAJ | 학술논문

目的：研究奥硝唑在辅助法莫替丁治疗慢性胃炎中对疗效及安全性的影响，为临床治疗提供指导。方法146例慢性胃炎患者，随机分为观察和对照两个研究组，每组73例。对照组给予法莫替丁片(20 mg，每日2次)治疗；观察组同时给予法莫替丁片(20 mg，每日2次)和奥硝唑片(25 mg，每日2次)治疗。1个月为一个疗程，连续治疗2个疗程后比较两组的疗效、安全性、治疗依从性。结果观察组总有效率为93.2%高于对照组82.2%；观察组复发率为8.2%低于对照组21.9%；观察组不良反应发生率为4.1%低于对照组13.7%；治疗依从性观察组优于对照组，P＜0.05，差异均具有统计学意义。结论奥硝唑辅助法莫替丁治疗慢性胃炎能够提高有效率，降低复发率，改善安全性及治疗的依从性。
목적：연구오초서재보조법막체정치료만성위염중대료효급안전성적영향，위림상치료제공지도。방법146례만성위염환자，수궤분위관찰화대조량개연구조，매조73례。대조조급여법막체정편(20 mg，매일2차)치료；관찰조동시급여법막체정편(20 mg，매일2차)화오초서편(25 mg，매일2차)치료。1개월위일개료정，련속치료2개료정후비교량조적료효、안전성、치료의종성。결과관찰조총유효솔위93.2%고우대조조82.2%；관찰조복발솔위8.2%저우대조조21.9%；관찰조불량반응발생솔위4.1%저우대조조13.7%；치료의종성관찰조우우대조조，P＜0.05，차이균구유통계학의의。결론오초서보조법막체정치료만성위염능구제고유효솔，강저복발솔，개선안전성급치료적의종성。
Objective To explore the ornidazole in auxiliary famotidine therapy on the efifcacy and safety of chronic gastritis, and provide guidance for clinical treatment.Methods 146 chronic gastritis patients were randomly separated into the observe group and the control group, 73 cases in each group. The control group received Famotidine (20 mg, bid/d). The observe group received Famotidine Tablets (20 mg, bid/d) and ornidazole tablets (25 mg, bid/d). One month is a treatment course. After two courses of continuous treatment, we compared the curative effect, safety, compliance between the two groups.Results Total effective rate 93.2% in the observe group was higher than 82.2% in the control group. The recurrence rate 8.2%in the observation group was lower than 21.9% in the control group. In the comparision of safety, the incidence adverse reactions in the observe group (4.1%) was lower than that in the control group (13.7%). The observe group was better than the control group in the treatment compliance (P<0.05) the difference had statistical signiifcance.Conclusion In the treatment of chronic gastritis, Ornidazole auxiliary famotidine can improve efifciency, reduce the recurrence rate, and improve safety and compliance of treatment.