CAJ | 학술논문

目的：探讨蛋白磷酸酶2A的癌性抑制因子（CIP2A）在前列腺癌组织中的表达及其与临床病理参数的关系。方法收集2011年12月至2014年11月该院泌尿外科前列腺癌（80例）和前列腺增生（25例）组织标本进行研究。应用RT-PCR和免疫组织化学分别检测标本组织中CIP2A mRNA和蛋白表达情况。结果 CIP2A在前列腺癌组织中的阳性表达率（70%，56/80）明显高于前列腺增生组织（16%，4/25），差异有统计学意义（P＜0.01），CIP2A在前列腺癌中表达与高Gleason评分、高T分期、淋巴结转移有关，差异均有统计学意义（P＜0.05），但CIP2A表达与前列腺特异性抗原（PSA）水平无明显相关性（P>0.05）。结论 CIP2A在前列腺癌的发生发展中可能起促进作用，与前列腺癌的发生、分化和淋巴结转移有一定关系，有可能成为判断前列腺癌预后的新标志和临床治疗的新靶点。
목적：탐토단백린산매2A적암성억제인자（CIP2A）재전렬선암조직중적표체급기여림상병리삼수적관계。방법수집2011년12월지2014년11월해원비뇨외과전렬선암（80례）화전렬선증생（25례）조직표본진행연구。응용RT-PCR화면역조직화학분별검측표본조직중CIP2A mRNA화단백표체정황。결과 CIP2A재전렬선암조직중적양성표체솔（70%，56/80）명현고우전렬선증생조직（16%，4/25），차이유통계학의의（P＜0.01），CIP2A재전렬선암중표체여고Gleason평분、고T분기、림파결전이유관，차이균유통계학의의（P＜0.05），단CIP2A표체여전렬선특이성항원（PSA）수평무명현상관성（P>0.05）。결론 CIP2A재전렬선암적발생발전중가능기촉진작용，여전렬선암적발생、분화화림파결전이유일정관계，유가능성위판단전렬선암예후적신표지화림상치료적신파점。
Objective To detect the expression of CIP2A of protein phosphatase 2A in prostate cancer tissues and to ex-plore its correlation with prostate cancer clinicopathological parameters. Methods It was collected tissue samples from 80 pa-tients with prostate cancer and 25 patients with prostatichyperplasia to explore further. The expression of CIP2A mRNA and pro-tein were detected by RT-PCR and immunohistochemistry. Results The positive rate of CIP2A in prostate cancer tissues (70%, 56/80) was significantly higher than that of benign prostatic hyperplasia tissues(16%,4/25),and there was a statistically signifi-cant difference(P<0.01). Increased expression of CIP2A was more often detected in prostate cancer with high Gleason scoring, advanced T stage,lymph node metastasis. It showed statistical significance in difference(P<0.05). It was detected that CIP2A ex-pressionhad rare correlation with PSA concentration(P>0.05). Conclusion CIP2A may play an important role in carcinogene-sis and progression of prostate cancer. The expression of CIP2A has a certain relationship with tumorigenesis ,differentiation and lymph node metastasis. CIP2A may be a sign for prognosis and new target for clinical treatment and of prostate cancer.