现代医药卫生
現代醫藥衛生
현대의약위생
MODERN MEDICINE HEALTH
2015年
9期
1287-1289
,共3页
蓝杰%朱彦%王冬青
藍傑%硃彥%王鼕青
람걸%주언%왕동청
抑郁症%脑/解剖学和组织学%体层摄影术,发射型计算机%边缘系统%葡萄糖,代谢%病例对照研究
抑鬱癥%腦/解剖學和組織學%體層攝影術,髮射型計算機%邊緣繫統%葡萄糖,代謝%病例對照研究
억욱증%뇌/해부학화조직학%체층섭영술,발사형계산궤%변연계통%포도당,대사%병례대조연구
Depressive disorder%Brain/anatomy&histology%Tomography,X-ray computed%Limbic system%Glucose,metabolism%Case-control studies
目的：探究首发抑郁症边缘系统神经细胞的葡萄糖代谢水平及豫驰时间（T2）变化情况。方法采用正电子发射计算机断层显像（PET-CT）扫描及高场MRI（T2WI序列）分别对20例健康受试者（健康组）及20例首发抑郁症患者（首发抑郁组）进行检查，检测边缘系统脑区的最大标准摄取值（SUVmax）及MRI T2值。结果与健康组比较，首发抑郁组患者左侧海马和左侧杏仁核的SUVmax及T2值均降低，差异有统计学意义（P＜0.05），右侧海马杏仁核的SUVmax及T2值未出现变化，差异无统计学意义（P＞0.05）；与健康组比较，首发抑郁组患者左侧前扣带回的SUVmax升高，差异有统计学意义（P＜0.05），右侧前扣带回的SUVmax及T2值未见变化，差异无统计学意义（P＞0.05）。结论首发抑郁症患者的边缘系统神经细胞受损体现在神经细胞的数目、完整性及对能量的摄取利用上，这些损害是抑郁症发生发展的一个重要机制。
目的：探究首髮抑鬱癥邊緣繫統神經細胞的葡萄糖代謝水平及豫馳時間（T2）變化情況。方法採用正電子髮射計算機斷層顯像（PET-CT）掃描及高場MRI（T2WI序列）分彆對20例健康受試者（健康組）及20例首髮抑鬱癥患者（首髮抑鬱組）進行檢查，檢測邊緣繫統腦區的最大標準攝取值（SUVmax）及MRI T2值。結果與健康組比較，首髮抑鬱組患者左側海馬和左側杏仁覈的SUVmax及T2值均降低，差異有統計學意義（P＜0.05），右側海馬杏仁覈的SUVmax及T2值未齣現變化，差異無統計學意義（P＞0.05）；與健康組比較，首髮抑鬱組患者左側前釦帶迴的SUVmax升高，差異有統計學意義（P＜0.05），右側前釦帶迴的SUVmax及T2值未見變化，差異無統計學意義（P＞0.05）。結論首髮抑鬱癥患者的邊緣繫統神經細胞受損體現在神經細胞的數目、完整性及對能量的攝取利用上，這些損害是抑鬱癥髮生髮展的一箇重要機製。
목적：탐구수발억욱증변연계통신경세포적포도당대사수평급예치시간（T2）변화정황。방법채용정전자발사계산궤단층현상（PET-CT）소묘급고장MRI（T2WI서렬）분별대20례건강수시자（건강조）급20례수발억욱증환자（수발억욱조）진행검사，검측변연계통뇌구적최대표준섭취치（SUVmax）급MRI T2치。결과여건강조비교，수발억욱조환자좌측해마화좌측행인핵적SUVmax급T2치균강저，차이유통계학의의（P＜0.05），우측해마행인핵적SUVmax급T2치미출현변화，차이무통계학의의（P＞0.05）；여건강조비교，수발억욱조환자좌측전구대회적SUVmax승고，차이유통계학의의（P＜0.05），우측전구대회적SUVmax급T2치미견변화，차이무통계학의의（P＞0.05）。결론수발억욱증환자적변연계통신경세포수손체현재신경세포적수목、완정성급대능량적섭취이용상，저사손해시억욱증발생발전적일개중요궤제。
Objective To study the first-episode depression limbic system changes of glucose metabolism of nerve cells and T2 signal changes. Methods Using PET-CT and MRI(T2WI series) to scan 20 first episode depression patients(the first episode group) and 20 healthy examinees(the healthy group),detecting the SUVmax and T2 valuesby MRI of the limbic systemre-spectively. Results Compared to the healthy group,the SUVmax and T2 values of left hippocampus and amygdaloid nucleus of first episode depression patients was reduced significantly,whose difference had statistical significance(P<0.05).The SUVmax and T2 values of right hippocampus and amygdaloid nucleus had no change. It had no statistical significance in difference (P>0.05);The SUVmax value of left anterior cingutate of first episode depression patients was increased ,whose difference had statistical signifi cance(P<0.05). There was no change in the SUVmax of the right anterior cingulate cortex or T2 value by MRI. It had no statistical significance in difference(P>0.05). Conclusion The nerve cells in limbic system of the first-episode depression patients have been damaged,reflecting in number,integrity of nerve cells and in take and utilization of energy. These damage become an im-portant mechanism of the development in depression.
