CAJ | 학술논문

在成骨细胞的分化增殖中，经典Wnt ／β－catenin通路起着重要的调节作用；此通路中的任何一个因子都能影响成骨细胞的分化增殖。近几年里，大量研究证明R－脊椎蛋白家族已成为Wnt／β－catenin信号通路的重要调节因子。本文就Rspo1通过Wnt ／β－catenin信号通路调控影响成骨细胞分化增殖的研究进展作一综述。
재성골세포적분화증식중，경전Wnt ／β－catenin통로기착중요적조절작용；차통로중적임하일개인자도능영향성골세포적분화증식。근궤년리，대량연구증명R－척추단백가족이성위Wnt／β－catenin신호통로적중요조절인자。본문취Rspo1통과Wnt ／β－catenin신호통로조공영향성골세포분화증식적연구진전작일종술。
The classic Wnt/β-catenin pathway plays a crucial role in the differentiation and proliferation of osteoblasts.Any factor in the pathway can affect the proliferation and differentiation of osteoblasts.In recent years, a large number of studies show that R-spondins ( RSPOs) is an important regulating factor in Wnt/β-catenin signaling pathway.This paper reviews the progress in Rspo1 regulation of osteoblast differentiation through Wnt/β-catenin signaling pathway.