CAJ | 학술논문

目的：了解四川大学华西医院的食管癌发病情况，侧面了解成都市乃至四川省的食管癌发病情况，探究食管癌临床病理特点，为食管癌的防治提供理论依据。方法选取1998年及2007年在四川大学华西医院就诊且诊断为食管癌的患者共1378例，逐项查阅病历，收集临床病理资料。结果2007年食管癌患者性别比例及食管癌各病理类型所占比例与1998年比较，差异均无统计学意义（P＞0.05）。在发病部位上，1998年与2007年均是中段食管癌患者所占比例最大，与其他部位食管癌比较，差异有统计学意义（P<0.01）。2007年食管癌平均发病年龄较1998年增大，女性食管癌中晚期患者所占比例低于男性患者，差异有统计学意义（P<0.01），而男女患者平均发病年龄、淋巴结转移率比较，差异均无统计学意义（P＞0.05）。与1998年比较，2007年食管癌患者早诊率（0~Ⅰ期）明显上升，Ⅱ期患者所占比例有所下降，差异均有统计学意义（P<0.05），男女患者均集中在Ⅱ~Ⅲ期，女性中晚期（Ⅲ~Ⅳ期）患者所占比例低于男性，差异均有统计学意义（P<0.05）。结论十年来，在四川大学华西医院住院就诊的食管癌患者平均发病年龄有所增加，各食管癌病理类型构成比无明显变化，男性患食管癌的可能性较女性大，且女性中晚期患者所占比例低于男性患者，应根据情况采取有针对性的预防措施。
목적：료해사천대학화서의원적식관암발병정황，측면료해성도시내지사천성적식관암발병정황，탐구식관암림상병리특점，위식관암적방치제공이론의거。방법선취1998년급2007년재사천대학화서의원취진차진단위식관암적환자공1378례，축항사열병력，수집림상병리자료。결과2007년식관암환자성별비례급식관암각병리류형소점비례여1998년비교，차이균무통계학의의（P＞0.05）。재발병부위상，1998년여2007년균시중단식관암환자소점비례최대，여기타부위식관암비교，차이유통계학의의（P<0.01）。2007년식관암평균발병년령교1998년증대，녀성식관암중만기환자소점비례저우남성환자，차이유통계학의의（P<0.01），이남녀환자평균발병년령、림파결전이솔비교，차이균무통계학의의（P＞0.05）。여1998년비교，2007년식관암환자조진솔（0~Ⅰ기）명현상승，Ⅱ기환자소점비례유소하강，차이균유통계학의의（P<0.05），남녀환자균집중재Ⅱ~Ⅲ기，녀성중만기（Ⅲ~Ⅳ기）환자소점비례저우남성，차이균유통계학의의（P<0.05）。결론십년래，재사천대학화서의원주원취진적식관암환자평균발병년령유소증가，각식관암병리류형구성비무명현변화，남성환식관암적가능성교녀성대，차녀성중만기환자소점비례저우남성환자，응근거정황채취유침대성적예방조시。
Objective To investigate the clinicopathologic features of esophageal cancer patients in West China Hospital of Sichuan University to know about epidemiologic characteristics of population with esophageal cancer in Sichuan province to pro-vide the theoretical basis for its prevention and treatment. Methods A total of 1 378 patients with esophageal cancer admitted in West China Hospital of Sichuan University in 1998 and 2007 were selected. All the clinicopathologic data and medical records were collected and analyzed term by term. Results There were no statistical significance in patients′gender and various patho-logical pattern proportion of esophageal cancer between 1998 and 2007,and the difference had no statistical significance(P>0.05). Concerning the pathogenic location,the mid piece esophageal cancer prevailed. Compared with other sites,it was statistically sig nificant in difference(P<0.01). The onset age in 2007 was older than that of 1998. The quantity of middle and terminal cancer in female patients with esophageal cancer was lower than that of the male. The difference had statistical significance (P<0.01). It had no statistical significance in mean attack age ,the male and female quantity in lymphatic metastasis ,and the difference had no sta-tistical significance(P>0.05). Compared to 1998,the early diagnosis rate of the patients with esophageal cancer(0-Ⅱphase) in 2007 was raised while proportion of the patients withⅡphase was declined,which had statistical significance in difference(P<0.05). The male and female patients focused onⅡ-Ⅲphase. The proportion of female patients involved in middle and terminal cancer (Ⅲ-Ⅳphase) was less than that of the male,which had statistical significance in difference(P<0.05). Conclusion In the late 10 years, the mean attack age hospitalized in West China Hospital of Sichuan University was increased but the pathological pat-tern of esophageal cancer barely varies. The men are more easily suffering from the disease than the women ,which should carry out countermeasures to prevention.