CAJ | 학술논문

目的：探讨术前中性粒细胞与淋巴细胞比值（NLR）及血小板与淋巴细胞比值（PLR）与甲状腺癌患者临床病理特征及预后的关系。方法回顾性收集2007年1月—2008年12月新疆医科大学第一附属医院收入的135例甲状腺癌患者的临床病理资料。按术前 NLR 分为 NLR≤3组（119例）和 NLR >3组（16例）；按术前 PLR 分为PLR≤150组（96例）和 PLR >150组（39例）。比较各组患者临床病理特征〔性别、年龄、民族、三碘甲状腺原氨酸（T3）、甲状腺素（T4）、甲状腺球蛋白（Tg）抗体、甲状腺过氧化物酶（TPO）抗体水平、有无桥本甲状腺炎、TNM分期、肿瘤大小、病理分型、有无淋巴结转移〕，采用 Logistic 回归分析术前 NLR、PLR 的影响因素，采用 Kaplan -Meier 法绘制生存曲线，并进行 Log - rank 检验。结果 NLR≤3组患者肿瘤大小与 NLR >3组比较，差异有统计学意义（P <0.05）。PLR≤150组患者肿瘤大小与 PLR >150组比较，差异有统计学意义（P <0.05）。Logistic 回归分析结果显示，民族、T3水平、肿瘤大小均是术前 NLR 的影响因素，肿瘤大小是术前 PLR 的影响因素（P <0.05）。NLR≤3组和NLR >3组患者生存曲线比较，差异无统计学意义（χ2=0.086，P =0.770）。PLR≤150组和 PLR >150组患者生存曲线比较，差异无统计学意义（χ2=1.721，P =0.190）。结论肿瘤大小是术前 NLR、PLR 的影响因素，但不同术前NLR、PLR 甲状腺癌患者的生存时间无差异。
목적：탐토술전중성립세포여림파세포비치（NLR）급혈소판여림파세포비치（PLR）여갑상선암환자림상병리특정급예후적관계。방법회고성수집2007년1월—2008년12월신강의과대학제일부속의원수입적135례갑상선암환자적림상병리자료。안술전 NLR 분위 NLR≤3조（119례）화 NLR >3조（16례）；안술전 PLR 분위PLR≤150조（96례）화 PLR >150조（39례）。비교각조환자림상병리특정〔성별、년령、민족、삼전갑상선원안산（T3）、갑상선소（T4）、갑상선구단백（Tg）항체、갑상선과양화물매（TPO）항체수평、유무교본갑상선염、TNM분기、종류대소、병리분형、유무림파결전이〕，채용 Logistic 회귀분석술전 NLR、PLR 적영향인소，채용 Kaplan -Meier 법회제생존곡선，병진행 Log - rank 검험。결과 NLR≤3조환자종류대소여 NLR >3조비교，차이유통계학의의（P <0.05）。PLR≤150조환자종류대소여 PLR >150조비교，차이유통계학의의（P <0.05）。Logistic 회귀분석결과현시，민족、T3수평、종류대소균시술전 NLR 적영향인소，종류대소시술전 PLR 적영향인소（P <0.05）。NLR≤3조화NLR >3조환자생존곡선비교，차이무통계학의의（χ2=0.086，P =0.770）。PLR≤150조화 PLR >150조환자생존곡선비교，차이무통계학의의（χ2=1.721，P =0.190）。결론종류대소시술전 NLR、PLR 적영향인소，단불동술전NLR、PLR 갑상선암환자적생존시간무차이。
Objectjve To investigate the relationship between preoperative blood neutrophil - to - lymphocyte ratio (NLR),preoperative blood platelet - to - lymphocyte ratio(PLR)and clinicopathological features,prognosis of patient with thyroid cancer. Methods 135 patients with thyroid cancer who were admitted to the First Affiliated Hospital of Xinjiang Medical Universtiy from January 2007 to December 2008,were selected as study subjects,the clinicopathological data of whom were collected retrospectively. According to the preoperative NLR value,subjects were divided into NLR≤3 group(119 cases)and NLR > 3 group(16 cases);according to the preoperative PLR value,subjects were divided into PLR≤150 group(96 cases) and PLR > 150 group(39 cases). The clinical pathology features(gender,age,nationality,levels of T3 ,T4 ,Tg and TPO, whether Hashimoto thyroiditis existed,TNM staging,tumor size,pathological type and whether lymph node metastasis existed) were compared among different groups of patients. The Logistic regression analysis was used to explore the influencing factors for preoperative NLR and PLR,survival curves were plotted by Kaplan - Meier method,and Log - rank test was performed. Results There was significant difference in tumor size between NLR≤3 group and NLR > 3 group(P < 0. 05). There was significant difference in tumor size between PLR≤150 group and PLR > 150 group(P < 0. 05). According to Logistic regression analysis results,tumor size,nationality and T3 level were the influencing factors for preoperative NLR(P < 0. 05),and tumor size was the influencing factor for preoperative PLR(P < 0. 05). There was no significant difference in survival time between NLR≤3 group and NLR > 3 group(χ2 = 0. 086,P = 0. 770),and there was no significant difference in survival time between PLR≤150 group and PLR > 150 group(χ2 = 1. 721,P = 0. 190). Conclusjon Tumor size is the influencing factor for preoperative NLR and PLR,but there is no significant difference in survival time among thyroid cancer patient groups with different preoperative NLR and PLR values.