中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2015年
9期
1685-1689
,共5页
多态性,单核苷酸%奥沙利铂%神经毒性
多態性,單覈苷痠%奧沙利鉑%神經毒性
다태성,단핵감산%오사리박%신경독성
Polymorphism,single nucleotide%Oxaliplatin%Neurotoxicity
随着肿瘤发病率的不断增加，奥沙利铂（OXA）已广泛应用于以大肠癌为主的各种肿瘤的治疗中，为患者延长寿命的同时，也给患者造成了不良反应，其中 OXA 导致周围神经系统毒性发生率高达90%。严重的周围神经系统毒性往往造成患者生活质量的下降，用药剂量被迫调整，甚至终止治疗，而达不到预期的治疗效果。最新研究显示多种指标可用于预测 OXA 相关的外周神经病变，为实现个体化药物治疗、提高化疗的连续性带来了希望。现对 OXA 周围神经毒性的临床特征、发生机制和基因多态性的最新进展作一综述。
隨著腫瘤髮病率的不斷增加，奧沙利鉑（OXA）已廣汎應用于以大腸癌為主的各種腫瘤的治療中，為患者延長壽命的同時，也給患者造成瞭不良反應，其中 OXA 導緻週圍神經繫統毒性髮生率高達90%。嚴重的週圍神經繫統毒性往往造成患者生活質量的下降，用藥劑量被迫調整，甚至終止治療，而達不到預期的治療效果。最新研究顯示多種指標可用于預測 OXA 相關的外週神經病變，為實現箇體化藥物治療、提高化療的連續性帶來瞭希望。現對 OXA 週圍神經毒性的臨床特徵、髮生機製和基因多態性的最新進展作一綜述。
수착종류발병솔적불단증가，오사리박（OXA）이엄범응용우이대장암위주적각충종류적치료중，위환자연장수명적동시，야급환자조성료불량반응，기중 OXA 도치주위신경계통독성발생솔고체90%。엄중적주위신경계통독성왕왕조성환자생활질량적하강，용약제량피박조정，심지종지치료，이체불도예기적치료효과。최신연구현시다충지표가용우예측 OXA 상관적외주신경병변，위실현개체화약물치료、제고화료적련속성대래료희망。현대 OXA 주위신경독성적림상특정、발생궤제화기인다태성적최신진전작일종술。
As the tumor incidence increased, oxaliplatin which is mainly composed of colorectal cancer has been widely used in the treatment of various tumors. These drugs not only prolong life of patients, but also bring a lot of adverse reactions at the same time. Among them the occurring rate of oxaliplatin-induced peripheral nervous system neuropathy is as high as 90%. Severe nervous system disorders tend to affect the quality of life of cancer survivors, force cancer survivors to reduce drug dosages, or even completely cease treatment, which will affect the expected results. The latest study shows a variety of indicators can be used to predict oxaliplatin-induced peripheral nervous system neuropathy, which bring the hope for improving the continuity of chemotherapy and realizing individualized drug therapy. This article reviewed the clinical characteristics, progress in pathogenesis, and gene polymorphism of oxaliplatin-induced peripheral neurotoxicity.
