中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2015年
9期
1706-1710
,共5页
血红素加氧酶-1%肾疾病%诱导剂%保护作用
血紅素加氧酶-1%腎疾病%誘導劑%保護作用
혈홍소가양매-1%신질병%유도제%보호작용
Heme oxygenase-1%Kidney diseases%Inducer%Protection
血红素加氧酶（HO）是血红素分解代谢过程中的起始酶和限速酶，它有三种同工酶分别为HO-1、HO-2和HO-3。其中HO-1为诱导型HO，它的降解产物一氧化碳、二价铁离子、胆绿素具有抗炎、抗氧化损伤、抗凋亡等作用。HO-1在多种肾脏疾病中均发挥重要的保护作用，诱导HO-1的高表达能够延缓肾脏疾病的进展。目前，已知多种化合物可以通过不同的途径诱导HO-1的表达，从而发挥保护肾脏的作用，减轻各种原因所致的肾脏损伤。现将HO-1及其诱导剂在肾脏疾病中的作用研究进展作一总结。
血紅素加氧酶（HO）是血紅素分解代謝過程中的起始酶和限速酶，它有三種同工酶分彆為HO-1、HO-2和HO-3。其中HO-1為誘導型HO，它的降解產物一氧化碳、二價鐵離子、膽綠素具有抗炎、抗氧化損傷、抗凋亡等作用。HO-1在多種腎髒疾病中均髮揮重要的保護作用，誘導HO-1的高錶達能夠延緩腎髒疾病的進展。目前，已知多種化閤物可以通過不同的途徑誘導HO-1的錶達，從而髮揮保護腎髒的作用，減輕各種原因所緻的腎髒損傷。現將HO-1及其誘導劑在腎髒疾病中的作用研究進展作一總結。
혈홍소가양매（HO）시혈홍소분해대사과정중적기시매화한속매，타유삼충동공매분별위HO-1、HO-2화HO-3。기중HO-1위유도형HO，타적강해산물일양화탄、이개철리자、담록소구유항염、항양화손상、항조망등작용。HO-1재다충신장질병중균발휘중요적보호작용，유도HO-1적고표체능구연완신장질병적진전。목전，이지다충화합물가이통과불동적도경유도HO-1적표체，종이발휘보호신장적작용，감경각충원인소치적신장손상。현장HO-1급기유도제재신장질병중적작용연구진전작일총결。
Heme oxygenase (HO), which has three kinds of isozyme HO-1, HO-2, HO-3, is the initial enzyme and restriction enzyme of heme in the procession of Catabolism In which HO-1 is an inducing HO, the effects of itself and HO degradation products of carbon monoxide, ferrous ion,biliverdin include anti-inflammation, anti-oxidative damage, anti-apoptosis and etc. HO-1 plays an important role in protecting all kinds of renal diseases. The increase of HO-1 expression can delay the progress of renal disease. At present, we have known that many compounds which can induce HO-1 expression through different pathways produce effect of protection and reduce the injury of renal diseases. Now we provided a summary of the mechanism of HO-1 and the compounds inducing HO-1 expression in renal diseases.
