中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2015年
4期
135-137
,共3页
脓毒症%参芪扶正注射液%高迁移率族蛋白-1
膿毒癥%參芪扶正註射液%高遷移率族蛋白-1
농독증%삼기부정주사액%고천이솔족단백-1
sepsis%Shenqi Fuzheng Injection%high mobility group protein -1
目的：观察采用参芪扶正注射液治疗小儿脓毒症的临床疗效及其对血清高迁移率族蛋白-1（ high mobility group protein 1，HMG-1）和肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）、乳酸（lactic acid ，LA ）、C-反应蛋白（C reactive protein， CRP）、降钙素原（ procalcitonin， PCT）水平的影响。方法选择本院治疗的140例脓毒症患儿，随机分成两组，观察组和对照组。两组均采用国家标准的脓毒症的治疗方法，对照组仅采用基础治疗，观察组在基础治疗的基础上加用参芪扶正注射液。观察两组临床疗效和血清HMG-1、TNF-α、LA、CRP、PCT水平。结果治疗后，观察组总有效率（95.71％）显著高于对照组（70.00％），χ2＝16.29，P＜0.01；治疗前2组HMG-1和TNF-α差异无统计学意义；治疗后，2组HMG-1、TNF-α显著低于各组治疗前（ P＜0.01）；与对照相比，治疗后HMG-1和TNF-α降低程度较观察组显著（P＜0.01）；治疗前观察组的血清中HMG-1与TNF-α两项数据呈正相关（r＝0.864， P＜0.05），观察组治疗前后的血清中HMG-1与TNF-α两项数据的分析结果也呈显著正相关（ r＝0.904， P＜0.05）；治疗后，2组LA、CRP、PCT均较本组治疗前有显著差异（P＜0.01）；且观察组较对照组降低更显著（P＜0.01）。结论采用参芪扶正注射液治疗小儿脓毒症效果显著。
目的：觀察採用參芪扶正註射液治療小兒膿毒癥的臨床療效及其對血清高遷移率族蛋白-1（ high mobility group protein 1，HMG-1）和腫瘤壞死因子-α（tumor necrosis factor-α，TNF-α）、乳痠（lactic acid ，LA ）、C-反應蛋白（C reactive protein， CRP）、降鈣素原（ procalcitonin， PCT）水平的影響。方法選擇本院治療的140例膿毒癥患兒，隨機分成兩組，觀察組和對照組。兩組均採用國傢標準的膿毒癥的治療方法，對照組僅採用基礎治療，觀察組在基礎治療的基礎上加用參芪扶正註射液。觀察兩組臨床療效和血清HMG-1、TNF-α、LA、CRP、PCT水平。結果治療後，觀察組總有效率（95.71％）顯著高于對照組（70.00％），χ2＝16.29，P＜0.01；治療前2組HMG-1和TNF-α差異無統計學意義；治療後，2組HMG-1、TNF-α顯著低于各組治療前（ P＜0.01）；與對照相比，治療後HMG-1和TNF-α降低程度較觀察組顯著（P＜0.01）；治療前觀察組的血清中HMG-1與TNF-α兩項數據呈正相關（r＝0.864， P＜0.05），觀察組治療前後的血清中HMG-1與TNF-α兩項數據的分析結果也呈顯著正相關（ r＝0.904， P＜0.05）；治療後，2組LA、CRP、PCT均較本組治療前有顯著差異（P＜0.01）；且觀察組較對照組降低更顯著（P＜0.01）。結論採用參芪扶正註射液治療小兒膿毒癥效果顯著。
목적：관찰채용삼기부정주사액치료소인농독증적림상료효급기대혈청고천이솔족단백-1（ high mobility group protein 1，HMG-1）화종류배사인자-α（tumor necrosis factor-α，TNF-α）、유산（lactic acid ，LA ）、C-반응단백（C reactive protein， CRP）、강개소원（ procalcitonin， PCT）수평적영향。방법선택본원치료적140례농독증환인，수궤분성량조，관찰조화대조조。량조균채용국가표준적농독증적치료방법，대조조부채용기출치료，관찰조재기출치료적기출상가용삼기부정주사액。관찰량조림상료효화혈청HMG-1、TNF-α、LA、CRP、PCT수평。결과치료후，관찰조총유효솔（95.71％）현저고우대조조（70.00％），χ2＝16.29，P＜0.01；치료전2조HMG-1화TNF-α차이무통계학의의；치료후，2조HMG-1、TNF-α현저저우각조치료전（ P＜0.01）；여대조상비，치료후HMG-1화TNF-α강저정도교관찰조현저（P＜0.01）；치료전관찰조적혈청중HMG-1여TNF-α량항수거정정상관（r＝0.864， P＜0.05），관찰조치료전후적혈청중HMG-1여TNF-α량항수거적분석결과야정현저정상관（ r＝0.904， P＜0.05）；치료후，2조LA、CRP、PCT균교본조치료전유현저차이（P＜0.01）；차관찰조교대조조강저경현저（P＜0.01）。결론채용삼기부정주사액치료소인농독증효과현저。
Objective To observe the clinical effects of Shenqi Fuzheng Injection in treatment of sepsis in children and its effect on the serum levels of high mobility group protein-1 and tumor necrosis factor-α, lactic acid, C reactive protein, procalcitonin levels.Methods 140 patients with sepsis were chosen, and randomly divided into two groups, the observation group and the control group.Two groups were given treatment by the national standard of sepsis, while the control group only received basic treatment, the observation group on the basis of conventional treatment combined with Shenqi Fuzheng injection.Two groups of clinical curative effect and the levels of serum HMG-1, TNF-α, LA, CRP, PCT level were observed. Results After treatment, the observation group total effective rate (95.71%) was significantly higher than control group (70.00%),χ2 =16.29, P<0.01.Two groups before treatment, TNF-αand HMG-1 had no statistically significant difference.After treatment, 2 groups of HMG -1, TNF-αsignificantly lower than before treatment (P<0.01),which HMG-1,and TNF-αreduced significantly in observation group (P<0.01).Serum HMG-1 were positively correlated with TNF-αbefore and after treatment (P<0.05).After treatment, LA, CRP and PCT in 2 groups were significantly different compared with before treatment (P<0.01), and the observation group decreased significantly than control group (P<0.01).Conclusion The effect of Shenqi Fuzheng Injection in the treatment of children with sepsis is significant, which is worthy of clinical application.
