CAJ | 학술논문

紫杉烷类抗肿瘤药物是一类微管蛋白稳定剂，临床上广泛应用于乳腺癌、卵巢癌、非小细胞肺癌及部分头颈部恶性肿瘤的治疗，并且被证实具有突出疗效，但其所致外周神经毒性仍然对患者生活质量及心理有着不同程度影响，严重者导致不能按计划完成化疗。本文就紫杉烷类抗肿瘤药物所致神经毒性的发病机制、影响因素、临床评估及预防、治疗等方面的研究进展加以总结，以期临床应用紫杉类抗肿瘤药物时能早期预防其外周神经毒性，在延长患者生存期的同时，提高其生活质量。
자삼완류항종류약물시일류미관단백은정제，림상상엄범응용우유선암、란소암、비소세포폐암급부분두경부악성종류적치료，병차피증실구유돌출료효，단기소치외주신경독성잉연대환자생활질량급심리유착불동정도영향，엄중자도치불능안계화완성화료。본문취자삼완류항종류약물소치신경독성적발병궤제、영향인소、림상평고급예방、치료등방면적연구진전가이총결，이기림상응용자삼류항종류약물시능조기예방기외주신경독성，재연장환자생존기적동시，제고기생활질량。
As a tubulin stabilizer, taxanes are widely used in the treatment of breast cancer, ovarian cancer, non-small-cell lung cancer (NSCLC),and part of head and neck malignant tumors, and were confirmed to be significantly effective.However, taxanes-induced peripheral neuropathy(TIPN) still affects the quality of life and psychological status of patients to varying degrees, severe cases can lead to dose reduction, and even chemotherapy interruption.In this paper, we summarize the pathogenesis, risk factors, clinical assessment, the progress of prevention and treatment of TIPN, to provide the basis for the prediction and early prevention of TIPN in the clinical administration, thus we can improve patients’ quality of life while extending their survival.