CAJ | 학술논문

蟾酥作为一种含有多种有效化学成分的传统中药，临床用途广泛。近年来蟾酥及其活性成分显著的抗肿瘤作用逐渐成为研究的热点，新近研究发现其作用机制与内质网应激、肿瘤相关性炎症、细胞自噬、线粒体介导的细胞凋亡通路、热休克蛋白及调节免疫等有关。本文将从以上方面对蟾酥不同活性成分抗肿瘤作用及其机制进行综述。
섬소작위일충함유다충유효화학성분적전통중약，림상용도엄범。근년래섬소급기활성성분현저적항종류작용축점성위연구적열점，신근연구발현기작용궤제여내질망응격、종류상관성염증、세포자서、선립체개도적세포조망통로、열휴극단백급조절면역등유관。본문장종이상방면대섬소불동활성성분항종류작용급기궤제진행종술。
Toad venom as a Chinese traditional natural medicine with a kind of effective chemical components has been widely used for many disease.Recently more and more research was focused on its remarkable antitumor efforts, new studies have found that the mechanism was closely associated with endoplasmic reticulum stress,tumor-related inflammation, autophagy, mitochondria-induced apoptosis pathway, heat chock protein and immuneomodulatory.In this article we reviewed the antitumor research advances of toad venom and its active compounds from several aspects mentioned above.