中国全科医学
中國全科醫學
중국전과의학
CHINESE GENERAL PRACTICE
2015年
13期
1587-1590
,共4页
耐甲氧西林金黄色葡萄球菌%耐甲氧西林凝固酶阴性球菌%检出率%抗菌药物使用强度%相关分析
耐甲氧西林金黃色葡萄毬菌%耐甲氧西林凝固酶陰性毬菌%檢齣率%抗菌藥物使用彊度%相關分析
내갑양서림금황색포도구균%내갑양서림응고매음성구균%검출솔%항균약물사용강도%상관분석
Methicillin-resistant staphylococcus aureus%Methicillin-resistant coagulase negative staphylococcus%Detection rate%Use intensity of antibacterial drugs%Correlation analysis
目的:探讨特殊耐药菌耐甲氧西林金黄色葡萄球菌( MRSA)、耐甲氧西林凝固酶阴性菌( MRCNS)与常用抗球菌药物使用强度之间的相关性,为合理选用抗菌药物,减少特殊耐药菌的产生提供依据。方法收集开封市儿童医院2009—2013年5年内细菌室上报数据和信息科抗菌药物相关数据,统计MRSA、MRCNS年检出率及常用抗菌药物使用强度,二者相关分析采用Pearson相关分析方法。结果 MRSA检出率与夫西地酸( r=0.951,P=0.013)、阿奇霉素(r=0.896,P=0.04)使用强度均呈极强正相关;而与头孢呋辛、头孢替安使用强度均无相关性(r值分别为-0.837、0.561,P﹥0.05)。MRCNS检出率与夫西地酸(r=0.980,P=0.03)、阿奇霉素(r=0.940,P=0.017)使用强度均呈极强正相关;而与头孢呋辛、头孢替安使用强度均无相关性(r值分别为-0.692、0.156,P﹥0.05)。结论夫西地酸、阿奇霉素易导致细菌耐药,不宜常规使用。严格控制临床抗菌药物使用,对延缓或避免细菌耐药性的产生有积极的意义。
目的:探討特殊耐藥菌耐甲氧西林金黃色葡萄毬菌( MRSA)、耐甲氧西林凝固酶陰性菌( MRCNS)與常用抗毬菌藥物使用彊度之間的相關性,為閤理選用抗菌藥物,減少特殊耐藥菌的產生提供依據。方法收集開封市兒童醫院2009—2013年5年內細菌室上報數據和信息科抗菌藥物相關數據,統計MRSA、MRCNS年檢齣率及常用抗菌藥物使用彊度,二者相關分析採用Pearson相關分析方法。結果 MRSA檢齣率與伕西地痠( r=0.951,P=0.013)、阿奇黴素(r=0.896,P=0.04)使用彊度均呈極彊正相關;而與頭孢呋辛、頭孢替安使用彊度均無相關性(r值分彆為-0.837、0.561,P﹥0.05)。MRCNS檢齣率與伕西地痠(r=0.980,P=0.03)、阿奇黴素(r=0.940,P=0.017)使用彊度均呈極彊正相關;而與頭孢呋辛、頭孢替安使用彊度均無相關性(r值分彆為-0.692、0.156,P﹥0.05)。結論伕西地痠、阿奇黴素易導緻細菌耐藥,不宜常規使用。嚴格控製臨床抗菌藥物使用,對延緩或避免細菌耐藥性的產生有積極的意義。
목적:탐토특수내약균내갑양서림금황색포도구균( MRSA)、내갑양서림응고매음성균( MRCNS)여상용항구균약물사용강도지간적상관성,위합리선용항균약물,감소특수내약균적산생제공의거。방법수집개봉시인동의원2009—2013년5년내세균실상보수거화신식과항균약물상관수거,통계MRSA、MRCNS년검출솔급상용항균약물사용강도,이자상관분석채용Pearson상관분석방법。결과 MRSA검출솔여부서지산( r=0.951,P=0.013)、아기매소(r=0.896,P=0.04)사용강도균정겁강정상관;이여두포부신、두포체안사용강도균무상관성(r치분별위-0.837、0.561,P﹥0.05)。MRCNS검출솔여부서지산(r=0.980,P=0.03)、아기매소(r=0.940,P=0.017)사용강도균정겁강정상관;이여두포부신、두포체안사용강도균무상관성(r치분별위-0.692、0.156,P﹥0.05)。결론부서지산、아기매소역도치세균내약,불의상규사용。엄격공제림상항균약물사용,대연완혹피면세균내약성적산생유적겁적의의。
Objective To investigate the correlation between the detection rate of MRSA and MRCNS and the use intensity of common antibacterial drugs in order to provide references for rational selection and use of antibacterial drugs and reduce the generation of special drug-resistance bacteria. Methods We collected relevant data from the bacteriology lab and the information section of Children's Hospital of Kaifeng from 2009 to 2013. The yearly detection rate of MRSA and MRCNS and the use intensity of common antibacterial drugs were calculated,and Pearson correlation analysis was conducted to examine the correlation between them. Results The detection rate of MRSA had a strong positive correlation with the use intensity of fusidic acid(r=0. 951,P=0. 013)and azithromycin(r=0. 896,P=0. 04)and had no correlation with cefuroxime(r= -0. 837, P﹥0. 05)and cefotiam(r=0. 561,P ﹥0. 05). The detection rate of MRCNS had a strong positive correlation with the use intensity of fusidic acid(r =0.980,P =0.03)and azithromycin(r =0.940,P =0.017)and had no correlation with cefuroxime(r= -0. 692,P﹥0. 05)and cefotiam(r=0. 156,P﹥0. 05). Conclusion Azithromycin and fusidic acid are not inappropriate for routine use,for they are likely to induce drug resistance. The strict control on the use of clinic antibacterial drugs is of significance to delay or prevent bacterial drug resistance.