实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
PRACTICAL JOURNAL OF CARDIAC CEREBRAL PNEUMAL AND VASCULAR DISEASE
2015年
3期
6-8
,共3页
心力衰竭%老年人%钠%利钠肽,脑%尿酸%心功能
心力衰竭%老年人%鈉%利鈉肽,腦%尿痠%心功能
심력쇠갈%노년인%납%리납태,뇌%뇨산%심공능
Heart failure%Aged%Sodium%Natriuretic peptide,brain%Uric acid%Heart funcion
目的：探讨老年心力衰竭急性发作期患者血钠（ Na）、B型钠尿肽（ BNP）和尿酸（ UA）水平变化及其与心功能的关系。方法选取2011—2013年重庆市永荣矿业有限公司总医院收治的老年心力衰竭急性发作期患者60例作为疾病组，选择同期老年心力衰竭稳定期患者60例作为疾病对照组，另选择同期门诊体检健康者70例作为对照组。比较3组受试者血Na、BNP、UA水平，比较疾病组不同心功能分级患者血Na、BNP、UA水平变化，分析其与心功能分级的相关性。结果疾病组患者血BNP、UA水平高于疾病对照组，血Na水平低于疾病对照组（ P<0.05）；疾病对照组患者血BNP、UA水平高于对照组，血Na水平低于对照组（ P<0.01）。疾病组患者中心功能分级Ⅳ级者血BNP、UA水平高于Ⅲ级者和Ⅱ级者，Ⅲ级者高于Ⅱ级者（P<0.05）；Ⅳ级者血Na水平低于Ⅲ级者和Ⅱ级者，Ⅲ级者低于Ⅱ级者（P<0.05）。Pearson相关分析结果显示，老年心力衰竭急性发作期患者血Na水平与心功能分级呈负相关（r=-0.602，P=0.006），血BNP水平与心功能分级呈正相关（r=0.551，P=0.012），血UA水平与心功能分级呈正相关（r=0.498，P=0.021）。结论老年心力衰竭急性发作期患者血BNP、UA水平升高，血Na水平降低，且血Na、BNP、UA水平与患者心功能分级相关。
目的：探討老年心力衰竭急性髮作期患者血鈉（ Na）、B型鈉尿肽（ BNP）和尿痠（ UA）水平變化及其與心功能的關繫。方法選取2011—2013年重慶市永榮礦業有限公司總醫院收治的老年心力衰竭急性髮作期患者60例作為疾病組，選擇同期老年心力衰竭穩定期患者60例作為疾病對照組，另選擇同期門診體檢健康者70例作為對照組。比較3組受試者血Na、BNP、UA水平，比較疾病組不同心功能分級患者血Na、BNP、UA水平變化，分析其與心功能分級的相關性。結果疾病組患者血BNP、UA水平高于疾病對照組，血Na水平低于疾病對照組（ P<0.05）；疾病對照組患者血BNP、UA水平高于對照組，血Na水平低于對照組（ P<0.01）。疾病組患者中心功能分級Ⅳ級者血BNP、UA水平高于Ⅲ級者和Ⅱ級者，Ⅲ級者高于Ⅱ級者（P<0.05）；Ⅳ級者血Na水平低于Ⅲ級者和Ⅱ級者，Ⅲ級者低于Ⅱ級者（P<0.05）。Pearson相關分析結果顯示，老年心力衰竭急性髮作期患者血Na水平與心功能分級呈負相關（r=-0.602，P=0.006），血BNP水平與心功能分級呈正相關（r=0.551，P=0.012），血UA水平與心功能分級呈正相關（r=0.498，P=0.021）。結論老年心力衰竭急性髮作期患者血BNP、UA水平升高，血Na水平降低，且血Na、BNP、UA水平與患者心功能分級相關。
목적：탐토노년심력쇠갈급성발작기환자혈납（ Na）、B형납뇨태（ BNP）화뇨산（ UA）수평변화급기여심공능적관계。방법선취2011—2013년중경시영영광업유한공사총의원수치적노년심력쇠갈급성발작기환자60례작위질병조，선택동기노년심력쇠갈은정기환자60례작위질병대조조，령선택동기문진체검건강자70례작위대조조。비교3조수시자혈Na、BNP、UA수평，비교질병조불동심공능분급환자혈Na、BNP、UA수평변화，분석기여심공능분급적상관성。결과질병조환자혈BNP、UA수평고우질병대조조，혈Na수평저우질병대조조（ P<0.05）；질병대조조환자혈BNP、UA수평고우대조조，혈Na수평저우대조조（ P<0.01）。질병조환자중심공능분급Ⅳ급자혈BNP、UA수평고우Ⅲ급자화Ⅱ급자，Ⅲ급자고우Ⅱ급자（P<0.05）；Ⅳ급자혈Na수평저우Ⅲ급자화Ⅱ급자，Ⅲ급자저우Ⅱ급자（P<0.05）。Pearson상관분석결과현시，노년심력쇠갈급성발작기환자혈Na수평여심공능분급정부상관（r=-0.602，P=0.006），혈BNP수평여심공능분급정정상관（r=0.551，P=0.012），혈UA수평여심공능분급정정상관（r=0.498，P=0.021）。결론노년심력쇠갈급성발작기환자혈BNP、UA수평승고，혈Na수평강저，차혈Na、BNP、UA수평여환자심공능분급상관。
Objective To investigate the changes of serum levels of sodium,BNP and uric acid in aged patients with acute exacerbation of heart failure and their correlations with cardiac function. Methods From 2011 to 2013 in the General Hospital of Yongrong Mining Limited Company of Chongqing,60 aged patients with acute exacerbation of heart failure were selected as A group,60 aged patients with stable heart failure were selected as B group,70 aged healthy cases were selected as C group. Serum levels of sodium,BNP and uric acid were detected and compared,and their correlations with cardiac function were analyzed. Results Serum levels of BNP and uric acid of A group were higher than those of B group,while serum sodium level was lower than that of B group ( P <0. 05 );serum levels of BNP and uric acid of B group were higher than those of C group,while serum sodium level was lower than that of C group(P<0. 05). In A group,serum levels of BNP and uric acid of patients withⅣ-stage cardiac function were higher than patients withⅢ- andⅡ-stage cardiac function,and those of patients with Ⅲ-stage cardiac function were higher than patients withⅡ-stage cardiac function ( P<0. 05 );serum sodium level of patients with Ⅳ-stage cardiac function was lower than patients with Ⅲ- andⅡ-stage cardiac function,and that of patients withⅢ-stage cardiac function was lower than patients withⅡ-stage cardiac function(P<0. 05). Pearson correlation analysis showed that,serum sodium level was negatively correlated with cardiac function of aged patients with acute exacerbation of heart failure(r= -0. 602,P=0. 006),while serum BNP level(r=0. 551,P=0. 012)and serum uric acid level(r=0. 551,P=0. 012) was positively correlated with cardiac function,respectively. Conclusion Serum levels of BNP and uric acid of aged patients with acute exacerbation of heart failure are high,while the serum sodium level is low,but all of them are correlated with the cardiac function.
