CAJ | 학술논문

目的：比较药物治疗、碘131治疗和手术治疗对甲状腺功能亢进患者骨密度以及骨代谢指标的影响。方法186名女性甲状腺功能亢进患者参加了本次研究，根据病情和患者自愿原则，接受药物治疗、碘131治疗或者手术治疗。比较治疗前以及治疗2年后3组患者骨密度和骨代谢指标的变化。结果3组患者治疗后较治疗前骨密度明显改善，骨代谢指标显著下降。而3组患者之间骨密度以及骨代谢指标无显著差别。结论药物、碘131和手术治疗均能有效改善甲状腺功能亢进患者骨密度，纠正骨代谢紊乱。
목적：비교약물치료、전131치료화수술치료대갑상선공능항진환자골밀도이급골대사지표적영향。방법186명녀성갑상선공능항진환자삼가료본차연구，근거병정화환자자원원칙，접수약물치료、전131치료혹자수술치료。비교치료전이급치료2년후3조환자골밀도화골대사지표적변화。결과3조환자치료후교치료전골밀도명현개선，골대사지표현저하강。이3조환자지간골밀도이급골대사지표무현저차별。결론약물、전131화수술치료균능유효개선갑상선공능항진환자골밀도，규정골대사문란。
Objective To evaluate the impact of drug therapy, radioiodine therapy, and surgical therapy in bone mineral density and biochemical bone turnover markers in patients with hyperthyroidism.Methods A total of 186 female patients with hyperthyroidism were enrolled in the study.They received drug therapy, radioiodine therapy, or surgical therapy according to the disease course and their own wish.Bone mineral density and biochemical bone turnover markers were compared at the time of enrollment and after 2-year treatment.Results Bone mineral density increased and biochemical bone turnover markers decreased significantly in all patients in 3 groups.No difference between bone mineral density and bone turnover markers were found among the 3 groups.Conclusion Drug therapy, radioiodine therapy, and surgical therapy improve bone mineral density and decrease biochemical markers of bone turnover in hyperthyroid patients.