实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
PRACTICAL JOURNAL OF CARDIAC CEREBRAL PNEUMAL AND VASCULAR DISEASE
2015年
3期
49-50,51
,共3页
高血压%肥大,左心室%心动过速,室性%比索洛尔%治疗结果
高血壓%肥大,左心室%心動過速,室性%比索洛爾%治療結果
고혈압%비대,좌심실%심동과속,실성%비색락이%치료결과
Hypertension%Hypertrophy,left ventricular%Tachycardia,ventricular%Bisoprolol%Treatment outcome
目的：探究比索洛尔治疗高血压左室肥厚的临床疗效及对室性心律失常的影响。方法选取2011年1月—2014年6月海丰县彭湃纪念医院收治的56例高血压左室肥厚患者，随机分为对照组和观察组，每组28例。对照组患者给予常规降压治疗，观察组患者在对照组基础上加用比索洛尔口服治疗。比较两组患者治疗前后左室舒张末内径（ LVDd）、左室后壁厚度（ LVPWT）、V2导联T波峰-末间期（ Tp-e间期）、QT离散度（ QTd）、室性心律失常发生率及不良反应发生率。结果两组患者治疗前LVDd、LVPWT比较，差异无统计学意义（ P>0.05）；观察组患者治疗后LVDd、LVPWT均小于对照组（ P<0.05）。两组患者治疗前V2导联Tp-e间期、QTd和室性心律失常发生率比较，差异无统计学意义（P>0.05）；观察组患者治疗后V2导联Tp-e间期、QTd均短于对照组，室性心律失常发生率低于对照组（P<0.05）。两组患者不良反应发生率比较，差异无统计学意义（P>0.05）。结论比索洛尔治疗高血压左室肥厚的临床疗效确切，可有效减轻患者左室肥厚程度，防治心律失常，改善预后。
目的：探究比索洛爾治療高血壓左室肥厚的臨床療效及對室性心律失常的影響。方法選取2011年1月—2014年6月海豐縣彭湃紀唸醫院收治的56例高血壓左室肥厚患者，隨機分為對照組和觀察組，每組28例。對照組患者給予常規降壓治療，觀察組患者在對照組基礎上加用比索洛爾口服治療。比較兩組患者治療前後左室舒張末內徑（ LVDd）、左室後壁厚度（ LVPWT）、V2導聯T波峰-末間期（ Tp-e間期）、QT離散度（ QTd）、室性心律失常髮生率及不良反應髮生率。結果兩組患者治療前LVDd、LVPWT比較，差異無統計學意義（ P>0.05）；觀察組患者治療後LVDd、LVPWT均小于對照組（ P<0.05）。兩組患者治療前V2導聯Tp-e間期、QTd和室性心律失常髮生率比較，差異無統計學意義（P>0.05）；觀察組患者治療後V2導聯Tp-e間期、QTd均短于對照組，室性心律失常髮生率低于對照組（P<0.05）。兩組患者不良反應髮生率比較，差異無統計學意義（P>0.05）。結論比索洛爾治療高血壓左室肥厚的臨床療效確切，可有效減輕患者左室肥厚程度，防治心律失常，改善預後。
목적：탐구비색락이치료고혈압좌실비후적림상료효급대실성심률실상적영향。방법선취2011년1월—2014년6월해봉현팽배기념의원수치적56례고혈압좌실비후환자，수궤분위대조조화관찰조，매조28례。대조조환자급여상규강압치료，관찰조환자재대조조기출상가용비색락이구복치료。비교량조환자치료전후좌실서장말내경（ LVDd）、좌실후벽후도（ LVPWT）、V2도련T파봉-말간기（ Tp-e간기）、QT리산도（ QTd）、실성심률실상발생솔급불량반응발생솔。결과량조환자치료전LVDd、LVPWT비교，차이무통계학의의（ P>0.05）；관찰조환자치료후LVDd、LVPWT균소우대조조（ P<0.05）。량조환자치료전V2도련Tp-e간기、QTd화실성심률실상발생솔비교，차이무통계학의의（P>0.05）；관찰조환자치료후V2도련Tp-e간기、QTd균단우대조조，실성심률실상발생솔저우대조조（P<0.05）。량조환자불량반응발생솔비교，차이무통계학의의（P>0.05）。결론비색락이치료고혈압좌실비후적림상료효학절，가유효감경환자좌실비후정도，방치심률실상，개선예후。
Objective To investigate the clinical effect of bisoprolol on hypertensive left ventricular hypertrophy and its impact on ventricular arrhythmias. Methods A total of 56 patients with hypertensive left ventricular hypertrophy were selected in Pengpai Memorial Hospital of Haifeng County from January 2011 to June 2014,and they were randomly divided into control group and observation group, each of 28 cases. Patients of control group were given conventional antihypertensive therapy,while patients of observation group were given extra bisoprolol based on the treatment of control group. Left ventricular end - diastolic diameter ( LVDd ), left ventricular posterior wall thickness ( LVPWT ), Tpeak - Tend interphase ( Tp - e interphase) of V2 lead, QT dispersion ( QTd ), incidence of ventricular arrhythmias and adverse reactions were compared between the two groups before and after treatment. Results No statistically significant differences of LVDd,LVPWT,Tp-e interphase of V2 lead,QTd and incidence of ventricular arrhythmias was found between the two groups before treatment( P>0. 05);LVDd and LVPWT of observation group were smaller than those of control group after treatment(P<0. 05),while Tp-e interphase of V2 lead, QTd were shorter, incidence of ventricular arrhythmias was lower ( P <0. 05 ). No statistically significant differences of incidence of adverse reactions was found between the two groups after treatment ( P > 0. 05 ). Conclusion Bisoprolol has certain clinical effect on hypertensive left ventricular hypertrophy,can effectively relieve the severity of left ventricular hypertrophy,reduce the incidence of ventricular arrhythmias and improve the prognosis.
