CAJ | 학술논문

骨质疏松症%糖尿病%骨关节炎%骨转换标志物%骨硬化素%PTH相关蛋白%甲状旁腺素%选择性组织蛋白酶K抑制剂%非典型股骨骨折%下颌骨坏死%序贯治疗骨質疏鬆癥%糖尿病%骨關節炎%骨轉換標誌物%骨硬化素%PTH相關蛋白%甲狀徬腺素%選擇性組織蛋白酶K抑製劑%非典型股骨骨摺%下頜骨壞死%序貫治療
골질소송증%당뇨병%골관절염%골전환표지물%골경화소%PTH상관단백%갑상방선소%선택성조직단백매K억제제%비전형고골골절%하합골배사%서관치료
Osteoporosis%Diabetes Mellitus%Osteoarthritis%Bone Turnover Marker%Sclerostin%PTH-related protein%Parathyroid%Cathepsin K inhibitors ( Odanacatib)%Atypical femur fracture ( AFF)%Osteonecrosis of the jaw%Sequential therapy

随着全球研究者和临床医师对骨质疏松症及骨代谢过程的认知逐步提高，骨质疏松领域的研究热点逐渐增多且研究方向逐渐清晰。首先，由于原发性骨质疏松症主要是一类老年性疾病，因此骨质疏松与其他年龄相关的慢性病有密切联系，在抗衰老机制的研究中，可以包含骨质疏松病因与治疗机制的研究；其次，随着现代成像技术的研发、微创器械的开发和其他诊断技术的突破，骨质疏松诊断和骨质量评估从过去单一的平面影像学测量矿物质含量，逐渐过渡到对骨强度、骨微结构、骨材料特性等多维度鉴定，使研究者能更准确地评估骨组织损害程度和药物作用；最后，抗骨质疏松药物治疗日趋靶向化，新药研发从细胞活性水平深入至信号传导通路水平，以提高药物效能，而临床上从单一用药推进至序贯和联合用药，或两者组合的给药策略，以便患者获得最长的骨保护期，并减少长期使用单一药物的严重不良事件。本文笔者回顾了2014年骨质疏松领域的重大研究结果，重点关注以下3方面：（1）骨质疏松与其他慢性病之间的联系；（2）骨质疏松诊断和骨折风险评估；（3）新药研发和临床治疗策略的研究。
수착전구연구자화림상의사대골질소송증급골대사과정적인지축보제고，골질소송영역적연구열점축점증다차연구방향축점청석。수선，유우원발성골질소송증주요시일류노년성질병，인차골질소송여기타년령상관적만성병유밀절련계，재항쇠로궤제적연구중，가이포함골질소송병인여치료궤제적연구；기차，수착현대성상기술적연발、미창기계적개발화기타진단기술적돌파，골질소송진단화골질량평고종과거단일적평면영상학측량광물질함량，축점과도도대골강도、골미결구、골재료특성등다유도감정，사연구자능경준학지평고골조직손해정도화약물작용；최후，항골질소송약물치료일추파향화，신약연발종세포활성수평심입지신호전도통로수평，이제고약물효능，이림상상종단일용약추진지서관화연합용약，혹량자조합적급약책략，이편환자획득최장적골보호기，병감소장기사용단일약물적엄중불량사건。본문필자회고료2014년골질소송영역적중대연구결과，중점관주이하3방면：（1）골질소송여기타만성병지간적련계；（2）골질소송진단화골절풍험평고；（3）신약연발화림상치료책략적연구。
With the increase of the understanding of osteoporosis by global researchers and clinicians, the research hotspot of osteoporosis field increases gradually and the research direction becomes gradually clear.First of all, because primary osteoporosis is mainly a kind of senile disease, it is closely linked to other chronic diseases in the elderly.The study of the anti-aging mechanism includes the study of etiology and mechanism of osteoporosis.Secondly, with the development of modern imaging technology and the breakthrough of minimally invasive devices and other diagnostic technology, the diagnosis of osteoporosis and assessment of bone quality advance from a single plane image to measure mineral content in the past, to the multi-dimension identification of bone strength, bone microstructure, and bone material properties.Researchers can evaluate the extent of bone damage and the effect of drugs more accurately.Finally, the anti-osteoporosis drug therapy becomes more targeted.The research and development of new drugs have advanced from cell activity level to signal transduction level in order to improve drug efficacy.The clinical medication has improved from the single drug use to sequential and combination use of the drug, so that patients obtain long bone protection period and reduced adverse events due to the long-term use of a single drug.The authors review the major findings in the osteoporosis field in 2014, and focus on the following 3 aspects:1) The correlation between osteoporosis and other chronic diseases;2) The diagnosis of osteoporosis and assessment of fracture risk;3)New drug development and clinical research of therapeutic strategies.