中华健康管理学杂志
中華健康管理學雜誌
중화건강관이학잡지
CHINESE JOURNAL OF HEALTH MANAGEMENT
2015年
2期
118-123
,共6页
糖化白蛋白%动脉硬化%同型半胱氨酸%脉搏波传导速度%收缩压
糖化白蛋白%動脈硬化%同型半胱氨痠%脈搏波傳導速度%收縮壓
당화백단백%동맥경화%동형반광안산%맥박파전도속도%수축압
Glycated albumin%Arterial stiffness%Homocysteine%Pulse wave velocity%Systolic pressure
目的：探讨体检人群中糖化白蛋白（GA）水平与动脉硬化的相关性的早期防治提供新途径。方法2012年1月至2014年6月在解放军总医院体检的18岁以上11014名，其中男性6187名（56.2%），女性4827名（43.8%），平均年龄为（46.8±7.8）岁，参加常规体检的研究对象进行问卷调查、血清GA和同型半胱氨酸（HCY）测定以及桡动脉-踝动脉脉搏波传导速度（baPWV）和中心动脉收缩压（cSBP）的检测。采用t检验、方差分析、卡方检验、多元回归分析以及分层分析GA与HCY、baPWV和cSBP的相关性。结果男性研究对象GA平均水平（13.69±2.69）低于女性（13.82±1.92）（t=2.78，P=0.005）。不管是男性还是女性，随着GA水平的升高，baPWV（男性：F=53.9，P<0.001；女性：F=37.7，P<0.001）和cSBP（男性：F=10.3，P<0.001；女性：F=13.5，P<0.001）水平逐渐升高。在校正年龄、高血压史、糖尿病史、家族糖尿病史、吸烟、体质指数、腰围、血压、血脂、肾功能、空腹血糖、餐后2 h血糖和糖化血红蛋白后，男性血清GA水平仍与baPWV（β=0.019；95%CI：0.002~0.036；P=0.032）和cSBP（β=0.251；95%CI：0.107~0.394；P=0.001）正相关。分层分析发现不管是否患有糖尿病或高血压，男性和女性血清GA均与baPWV和cSBP相关（P<0.05）。但GA与HCY的相关性不显著。结论在体检人群中，不管是男性还是女性以及是否患有糖尿病或高血压，血清GA水平均与baPWV和cSBP正相关。这种相关性在校正常规危险因素以及血糖指标后仍存在。提示GA可能是一个对于动脉硬化有预测价值的指标。
目的：探討體檢人群中糖化白蛋白（GA）水平與動脈硬化的相關性的早期防治提供新途徑。方法2012年1月至2014年6月在解放軍總醫院體檢的18歲以上11014名，其中男性6187名（56.2%），女性4827名（43.8%），平均年齡為（46.8±7.8）歲，參加常規體檢的研究對象進行問捲調查、血清GA和同型半胱氨痠（HCY）測定以及橈動脈-踝動脈脈搏波傳導速度（baPWV）和中心動脈收縮壓（cSBP）的檢測。採用t檢驗、方差分析、卡方檢驗、多元迴歸分析以及分層分析GA與HCY、baPWV和cSBP的相關性。結果男性研究對象GA平均水平（13.69±2.69）低于女性（13.82±1.92）（t=2.78，P=0.005）。不管是男性還是女性，隨著GA水平的升高，baPWV（男性：F=53.9，P<0.001；女性：F=37.7，P<0.001）和cSBP（男性：F=10.3，P<0.001；女性：F=13.5，P<0.001）水平逐漸升高。在校正年齡、高血壓史、糖尿病史、傢族糖尿病史、吸煙、體質指數、腰圍、血壓、血脂、腎功能、空腹血糖、餐後2 h血糖和糖化血紅蛋白後，男性血清GA水平仍與baPWV（β=0.019；95%CI：0.002~0.036；P=0.032）和cSBP（β=0.251；95%CI：0.107~0.394；P=0.001）正相關。分層分析髮現不管是否患有糖尿病或高血壓，男性和女性血清GA均與baPWV和cSBP相關（P<0.05）。但GA與HCY的相關性不顯著。結論在體檢人群中，不管是男性還是女性以及是否患有糖尿病或高血壓，血清GA水平均與baPWV和cSBP正相關。這種相關性在校正常規危險因素以及血糖指標後仍存在。提示GA可能是一箇對于動脈硬化有預測價值的指標。
목적：탐토체검인군중당화백단백（GA）수평여동맥경화적상관성적조기방치제공신도경。방법2012년1월지2014년6월재해방군총의원체검적18세이상11014명，기중남성6187명（56.2%），녀성4827명（43.8%），평균년령위（46.8±7.8）세，삼가상규체검적연구대상진행문권조사、혈청GA화동형반광안산（HCY）측정이급뇨동맥-과동맥맥박파전도속도（baPWV）화중심동맥수축압（cSBP）적검측。채용t검험、방차분석、잡방검험、다원회귀분석이급분층분석GA여HCY、baPWV화cSBP적상관성。결과남성연구대상GA평균수평（13.69±2.69）저우녀성（13.82±1.92）（t=2.78，P=0.005）。불관시남성환시녀성，수착GA수평적승고，baPWV（남성：F=53.9，P<0.001；녀성：F=37.7，P<0.001）화cSBP（남성：F=10.3，P<0.001；녀성：F=13.5，P<0.001）수평축점승고。재교정년령、고혈압사、당뇨병사、가족당뇨병사、흡연、체질지수、요위、혈압、혈지、신공능、공복혈당、찬후2 h혈당화당화혈홍단백후，남성혈청GA수평잉여baPWV（β=0.019；95%CI：0.002~0.036；P=0.032）화cSBP（β=0.251；95%CI：0.107~0.394；P=0.001）정상관。분층분석발현불관시부환유당뇨병혹고혈압，남성화녀성혈청GA균여baPWV화cSBP상관（P<0.05）。단GA여HCY적상관성불현저。결론재체검인군중，불관시남성환시녀성이급시부환유당뇨병혹고혈압，혈청GA수평균여baPWV화cSBP정상관。저충상관성재교정상규위험인소이급혈당지표후잉존재。제시GA가능시일개대우동맥경화유예측개치적지표。
Objective Serum glycated albumin (GA) is associated with the levels of blood glucose and short term glycemic fluctuation. The aim of this study was to investigate the associations between GA and arterial stiffness in a health screening population. Method A total of 11 014 participants (men, 56.2%;mean age, 46.8±7.8 years) who attended physical examination were invited and had completed standardized questionnaires. Serum GA and homocysteine (HCY), brachial-ankle pulse wave velocity (baPWV), and central systolic blood pressure (cSBP) were measured. A series of single and multiple factor analyses and stratified analysis were performed. Result The mean level of serum GA was lower in men (13.69 ± 2.69) than in women (13.82 ± 1.92) (t=2.78, P=0.005). The values of baPWV (men: F=53.9, P for trend<0.001;women:F=37.7, P for trend<0.001) and cSBP (men:F=10.3, P for trend<0.001;women:F=13.5, P for trend<0.001) increased with quartiles of GA levels in both men and women. After adjustment for age, history of hypertension, diabetes, family history of diabetes, smoking status, body mass index, waist circumference, blood pressure, blood lipids, kidney function, fasting glucose, postprandial glucose, and hemoglobin A1c, GA was positively associated with baPWV (βestimate, 0.019;95%CI:0.002-0.036;P=0.032) and cSBP (βestimate, 0.251; 95% CI: 0.107-0.394; P=0.001) in men. Stratified analysis also showed that the positive associations of GA with baPWV and cSBP remained significant in men both with and without diabetes or hypertension (P<0.05). However, the association between GA and HCY was not significant in multifactor analysis and stratified analysis. The above results were similar in women. Conclusion Serum GA levels were positively associated with baPWV and cSBP not only in patients with diabetes or hypertension but also in participants without diabetes or hypertension after adjusting for conventional factors and glucose markers. The findings suggest that GA may help detect the development of arterial stiffness in the health screening population.
