实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
PRACTICAL JOURNAL OF CARDIAC CEREBRAL PNEUMAL AND VASCULAR DISEASE
2015年
3期
71-73
,共3页
胎粪吸入综合征%婴儿,新生%猪肺磷脂注射液%治疗结果
胎糞吸入綜閤徵%嬰兒,新生%豬肺燐脂註射液%治療結果
태분흡입종합정%영인,신생%저폐린지주사액%치료결과
Meconium aspiration syndrome%Infant,newborn%Poractant alfa injection%Treatment outcome
目的:探究猪肺磷脂注射液治疗新生儿重症胎粪吸入性肺炎的临床疗效。方法选取2012年1月—2014年6月南华大学第一附属医院儿科收治的60例重症胎粪吸入性肺炎患儿,随机分为观察组和对照组,每组30例。对照组患儿给予常规治疗,观察组患儿在常规治疗的基础上给予猪肺磷脂注射液治疗。比较两组患儿治疗前与治疗后2 h、12 h、24 h动脉血氧分压( PaO2)、动脉血氧分压/吸入气氧浓度( PaO2/FiO2),观察两组患儿使用呼吸机时间、吸氧时间及住院时间。结果两组患儿治疗前PaO2、PaO2/FiO2比较,差异无统计学意义( P>0.05);观察组患儿治疗后2 h、12 h、24 h PaO2、PaO2/FiO2均高于对照组(P<0.05)。观察组患儿使用呼吸机时间、吸氧时间及住院时间均短于对照组(P<0.05)。结论猪肺磷脂注射液治疗新生儿重症胎粪吸入性肺炎的临床疗效确切,能有效改善患儿氧合状态,缩短患儿使用呼吸机时间、吸氧时间及住院时间。
目的:探究豬肺燐脂註射液治療新生兒重癥胎糞吸入性肺炎的臨床療效。方法選取2012年1月—2014年6月南華大學第一附屬醫院兒科收治的60例重癥胎糞吸入性肺炎患兒,隨機分為觀察組和對照組,每組30例。對照組患兒給予常規治療,觀察組患兒在常規治療的基礎上給予豬肺燐脂註射液治療。比較兩組患兒治療前與治療後2 h、12 h、24 h動脈血氧分壓( PaO2)、動脈血氧分壓/吸入氣氧濃度( PaO2/FiO2),觀察兩組患兒使用呼吸機時間、吸氧時間及住院時間。結果兩組患兒治療前PaO2、PaO2/FiO2比較,差異無統計學意義( P>0.05);觀察組患兒治療後2 h、12 h、24 h PaO2、PaO2/FiO2均高于對照組(P<0.05)。觀察組患兒使用呼吸機時間、吸氧時間及住院時間均短于對照組(P<0.05)。結論豬肺燐脂註射液治療新生兒重癥胎糞吸入性肺炎的臨床療效確切,能有效改善患兒氧閤狀態,縮短患兒使用呼吸機時間、吸氧時間及住院時間。
목적:탐구저폐린지주사액치료신생인중증태분흡입성폐염적림상료효。방법선취2012년1월—2014년6월남화대학제일부속의원인과수치적60례중증태분흡입성폐염환인,수궤분위관찰조화대조조,매조30례。대조조환인급여상규치료,관찰조환인재상규치료적기출상급여저폐린지주사액치료。비교량조환인치료전여치료후2 h、12 h、24 h동맥혈양분압( PaO2)、동맥혈양분압/흡입기양농도( PaO2/FiO2),관찰량조환인사용호흡궤시간、흡양시간급주원시간。결과량조환인치료전PaO2、PaO2/FiO2비교,차이무통계학의의( P>0.05);관찰조환인치료후2 h、12 h、24 h PaO2、PaO2/FiO2균고우대조조(P<0.05)。관찰조환인사용호흡궤시간、흡양시간급주원시간균단우대조조(P<0.05)。결론저폐린지주사액치료신생인중증태분흡입성폐염적림상료효학절,능유효개선환인양합상태,축단환인사용호흡궤시간、흡양시간급주원시간。
Objective To observe the clinical effect of poractant alfa injection on severe meconium aspiration pneumonia in newborns. Methods From January 2012 to June 2014,a total of 60 newborns with severe meconium aspiration pneumonia were selected in the Department of Pediatrics,the First Affiliated Hospital of Nanhua University,and they were randomly divided into control group and observation group,each of 30 cases. Newborns of control group were given conventional therapy,while newborns of observation group were given poractant alfa injection based on conventional therapy. PaO2,PaO2/FiO2 before treatment and 2 -,12 -,24 -hour after treatment were compared between the two groups,and ventilator using time,oxygen inhalation time and hospital stays were recorded. Results No statistically significant differences of PaO2 or PaO2/FiO2 was found between the two groups before treatment ( P >0. 05 );while PaO2 and PaO2/FiO2 of observation group were higher than those of control group 2 -,12 -,24 -hour after treatment,respectively(P <0. 05). Ventilator using time, oxygen inhalation time and hospital stays of observation group were shorter than those of control group(P<0. 05). Conclusion Poractant alfa injection has certain clinical effect on severe meconium aspiration pneumonia in newborns, can effectively improve the oxygenation state,shorten the ventilator using time,oxygen inhalation time and hospital stays.