中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2015年
4期
77-80
,共4页
依达拉奉%急性脑梗死%炎症因子%6-酮-前列腺素F1α%血栓素B2%血管内皮功能%和肽素%N末端脑钠素原
依達拉奉%急性腦梗死%炎癥因子%6-酮-前列腺素F1α%血栓素B2%血管內皮功能%和肽素%N末耑腦鈉素原
의체랍봉%급성뇌경사%염증인자%6-동-전렬선소F1α%혈전소B2%혈관내피공능%화태소%N말단뇌납소원
Keywords ] edaravone%acute cerebral infarction%inflammatory factors%6-keto-PGF1α%thromboxane B2%endothelial function%copeptin%N-terminal natriuretic peptide
目的：探讨依达拉奉对急性脑梗死患者血清炎症因子、6-酮-前列腺素F1α（6-keto-prostaglandin F1α，6-keto-PGF1α）、血栓素B2、血管内皮功能及血清和肽素和N末端脑钠素原（ N-terminal brain natriuretic peptide，NT-proBNP）的影响。方法选择自2013年3月～2014年9月期间郑州大学第五附属医院收治的213例急性脑梗死患者随机分为对照组（ n＝101）和观察组（ n＝112）。对照组采用常规对症治疗，观察组在对照组基础上结合依达拉奉注射液治疗。对比分析2组血清炎症因子、6-keto-PGF1α、血栓素B2、血管内皮功能、血清和肽素、NT-proBNP及神经功能评分和日常生活能力（ activities of daily living，ADL）评分。结果观察组治疗后血清C-反应蛋白（C-reactive protein，CRP）、白介素-8（interleukin-8，IL-8）、白介素-10（interleukin-10，IL-10）显著低于对照组（P＜0.05）；观察组治疗后血浆血栓素B2显著低于对照组（P＜0.05），6-keto-PGF1α显著高于对照组（P＜0.05）；观察组治疗后血清和肽素、NT-proBNP水平显著低于对照组（P＜0.05）；观察组治疗后血浆内皮素-1（endothelin-1，ET-1）显著低于对照组（P＜0.05），血浆一氧化氮（nitric oxide，NO）显著高于对照（P＜0.05）；观察组治疗后神经功能评分显著低于对照组（P＜0.05），ADL评分显著高于对照组（P＜0.05）。结论通过初步研究发现，依达拉奉治疗急性脑梗死机制可能与降低血清炎症因子、增加6-keto-PGF1α和降低血栓素B2、改善血管内皮功能及降低血清和肽素和N末端钠素原相关，具有重要意义。
目的：探討依達拉奉對急性腦梗死患者血清炎癥因子、6-酮-前列腺素F1α（6-keto-prostaglandin F1α，6-keto-PGF1α）、血栓素B2、血管內皮功能及血清和肽素和N末耑腦鈉素原（ N-terminal brain natriuretic peptide，NT-proBNP）的影響。方法選擇自2013年3月～2014年9月期間鄭州大學第五附屬醫院收治的213例急性腦梗死患者隨機分為對照組（ n＝101）和觀察組（ n＝112）。對照組採用常規對癥治療，觀察組在對照組基礎上結閤依達拉奉註射液治療。對比分析2組血清炎癥因子、6-keto-PGF1α、血栓素B2、血管內皮功能、血清和肽素、NT-proBNP及神經功能評分和日常生活能力（ activities of daily living，ADL）評分。結果觀察組治療後血清C-反應蛋白（C-reactive protein，CRP）、白介素-8（interleukin-8，IL-8）、白介素-10（interleukin-10，IL-10）顯著低于對照組（P＜0.05）；觀察組治療後血漿血栓素B2顯著低于對照組（P＜0.05），6-keto-PGF1α顯著高于對照組（P＜0.05）；觀察組治療後血清和肽素、NT-proBNP水平顯著低于對照組（P＜0.05）；觀察組治療後血漿內皮素-1（endothelin-1，ET-1）顯著低于對照組（P＜0.05），血漿一氧化氮（nitric oxide，NO）顯著高于對照（P＜0.05）；觀察組治療後神經功能評分顯著低于對照組（P＜0.05），ADL評分顯著高于對照組（P＜0.05）。結論通過初步研究髮現，依達拉奉治療急性腦梗死機製可能與降低血清炎癥因子、增加6-keto-PGF1α和降低血栓素B2、改善血管內皮功能及降低血清和肽素和N末耑鈉素原相關，具有重要意義。
목적：탐토의체랍봉대급성뇌경사환자혈청염증인자、6-동-전렬선소F1α（6-keto-prostaglandin F1α，6-keto-PGF1α）、혈전소B2、혈관내피공능급혈청화태소화N말단뇌납소원（ N-terminal brain natriuretic peptide，NT-proBNP）적영향。방법선택자2013년3월～2014년9월기간정주대학제오부속의원수치적213례급성뇌경사환자수궤분위대조조（ n＝101）화관찰조（ n＝112）。대조조채용상규대증치료，관찰조재대조조기출상결합의체랍봉주사액치료。대비분석2조혈청염증인자、6-keto-PGF1α、혈전소B2、혈관내피공능、혈청화태소、NT-proBNP급신경공능평분화일상생활능력（ activities of daily living，ADL）평분。결과관찰조치료후혈청C-반응단백（C-reactive protein，CRP）、백개소-8（interleukin-8，IL-8）、백개소-10（interleukin-10，IL-10）현저저우대조조（P＜0.05）；관찰조치료후혈장혈전소B2현저저우대조조（P＜0.05），6-keto-PGF1α현저고우대조조（P＜0.05）；관찰조치료후혈청화태소、NT-proBNP수평현저저우대조조（P＜0.05）；관찰조치료후혈장내피소-1（endothelin-1，ET-1）현저저우대조조（P＜0.05），혈장일양화담（nitric oxide，NO）현저고우대조（P＜0.05）；관찰조치료후신경공능평분현저저우대조조（P＜0.05），ADL평분현저고우대조조（P＜0.05）。결론통과초보연구발현，의체랍봉치료급성뇌경사궤제가능여강저혈청염증인자、증가6-keto-PGF1α화강저혈전소B2、개선혈관내피공능급강저혈청화태소화N말단납소원상관，구유중요의의。
Objective To investigate effect of edaravone on serum inflammatory factors, 6-keto-prostaglandin F1α(6-keto-PGF1α), thromboxane B2, endothelial function and serum copeptin and N-terminal brain natriuretic peptide (NT-proBNP) in patients with acute cerebral infarction.Methods From March 2013 to September 2014, 213 cases of acute cerebral infarction were selected in the hospital and randomly divided into control group (n=101) and observation group (n =112).Control group were given conventional symptomatic treatment, and observation group were given edaravone injection on the basis of control group.The serum inflammatory cytokines, 6-keto-PGF1α, thromboxane B2, endothelial function, serum copeptin, NT-proBNP and nerve function score and activities of daily living ( ADL) score were compared between two groups.Results Serum CRP, IL-8, IL-10 in observation group after treatment were significantly lower than control group (P<0.05).Plasma thromboxane B2 in observation group after treatment was significantly lower than control group (P<0.05).The levels of 6-keto-PGF1αwas significantly higher than control group (P<0.05).Serum copeptin and NT-proBNP levels in observation group after treatment were significantly lower than control group (P<0.05).Plasma ET-1 in observation group after treatment was significantly lower than control group ( P<0.05 ) , and plasma NO was significantly higher than the control ( P<0.05 ).Neurological function in observation group after treatment was significantly lower than control group (P<0.05), and ADL score was significantly higher (P<0.05). Conclusion The preliminary study shows that edaravone in treatment of acute cerebral infarction may be associated with decreasing serum inflammatory cytokines, increasing 6-keto-PGF1αand reducing thromboxane B2, improving endothelial function and reducing serum copeptin and N-terminal natriuretic peptide.
