CAJ | 학술논문

目的：探讨甲钴胺治疗脊髓神经损伤后的神经修复作用研究。方法选择2010年4月～2014年4月治疗的急性脊髓损伤患者108例，其中男60例，女48例，随机分为2组，甲钴胺组和对照组，其中甲钴胺组56例，给于甲钴胺治疗；对照组52例，给予常规治疗（地塞米松静脉滴注）。参照美国脊髓损伤评分标准（ ASIA）制定感觉功能、运动功能和脊髓功能评分标准，观察并记录2组患者治疗6周和随访6个月后的感觉功能、运动功能、神经功能恢复情况和并发症。结果脊髓神经损伤患者伤后6周及6个月随访时，甲钴胺组患者的感觉和运动功能的改善情况显著优于对照组（ P＜0.05）；甲钴胺组患者治疗后第1～3周神经功能恢复率显著优于较对照组（ P＜0.05）；2组均出现了泌尿感染、肺部感染、呕吐、反应性溃疡等并发症，但差异无统计学意义。结论急性脊髓损伤患者给予甲钴胺治疗，能够改善神经功能受损状况，有利于提高其预后生活质量。
목적：탐토갑고알치료척수신경손상후적신경수복작용연구。방법선택2010년4월～2014년4월치료적급성척수손상환자108례，기중남60례，녀48례，수궤분위2조，갑고알조화대조조，기중갑고알조56례，급우갑고알치료；대조조52례，급여상규치료（지새미송정맥적주）。삼조미국척수손상평분표준（ ASIA）제정감각공능、운동공능화척수공능평분표준，관찰병기록2조환자치료6주화수방6개월후적감각공능、운동공능、신경공능회복정황화병발증。결과척수신경손상환자상후6주급6개월수방시，갑고알조환자적감각화운동공능적개선정황현저우우대조조（ P＜0.05）；갑고알조환자치료후제1～3주신경공능회복솔현저우우교대조조（ P＜0.05）；2조균출현료비뇨감염、폐부감염、구토、반응성궤양등병발증，단차이무통계학의의。결론급성척수손상환자급여갑고알치료，능구개선신경공능수손상황，유리우제고기예후생활질량。
Objective To explore the repair effect of methylcobalamin treatment of nerve after spinal cord injury.Methods 108 cases of patients with acute spinal cord injury were selected treated in our hospital from 2010 April to 2014 April , including 60 cases of male, female 48 cases, were randomly divided into Mecobalamin group(n=56) and control group(n=52), mecobalamin group was treat with a cobalt amine, control group was given conventional treatment (dexamethasone intravenous drip note).According to American spinal cord injury score (ASIA) to set sensory function, motor function and spinal cord function score criteria, observed and record ed the sensory function, motor function, recovery of neurological function and complications the two groups of patients were treated for 6 weeks and followed up for 6 months.Results Spinal cord injury patients after 6 weeks and 6 months follow-up, the improvement of sensory and motor function of mecobalamin group were significantly better than the control group ( P <0.01 );Mecobalamin group patients after first to 3 weeks of recovery of neurological function was higher than those of the control group (P<0.05);the 2 groups were found urinary tract infections, lung infections, vomiting, reaction of ulcer complications, but the difference was not statistically significant ( P>0.05).Conclusion In patients with acute spinal cord injury treated by mecobalamin treatment can improve the nerve function damage condition, improve the prognosis and quality of life.