CAJ | 학술논문

目的：探讨柿叶提取物干预治疗对缺血性脑血管病患者二级预防的临床疗效，以及对缺血性脑血管病患者在血压、血糖、血脂、血液流变学、血流速度、血同型半胱氨酸等指标水平的影响。方法选取2013年1月～2013年12月在武汉市东湖医院就诊的缺血性脑血管病患者200例，随机分为对照组与观察组各100例，对照组予以神经内科常规治疗，观察组在对照组基础上给予柿叶提取物干预治疗，记录比较2组治疗前、治疗3、6个月后缺血性脑血管病的复发率及血压、血糖、血脂、血液流变学、血流速度、血同型半胱氨酸等指标水平。结果治疗3月末，观察组复发率4.40％，对照组复发率3.70％；治疗6月末，观察组复发率8.24％，对照组复发率13.75％，但2组比较差异均无统计学意义。2组治疗6月末收缩压、舒张压比治疗前下降，且观察组下降较对照组显著（均P＜0.05）。2组治疗3、6月末与治疗前比较，血清TC、TG、LDLC水平下降，HDLC水平升高；观察组治疗6月末上述指标变化较3月末显著；治疗6月末观察组上述指标较对照组变化显著（均P＜0.05）。2组治疗3、6月末FBG、2hPG以及HbA1C较治疗前下降显著；2组治疗6月末上述指标降低水平较3月末显著；观察组3、6月末上述指标下降较对照组同时点显著（均P＜0.05）。2组治疗3、6月末血清HCY水平较治疗前下降显著；观察组治疗3、6月末血清HCY水平较对照组同时点下降显著（均P＜0.05）。2组治疗6月末血液流变学各指标较治疗前改善显著；治疗6月末观察组血液流变学各指标较对照组改善显著（均P＜0.05）。2组治疗6月末脑部主要动脉血流速度均较治疗前显著升高；治疗6月末观察组与对照组脑部主要动脉血流速度变化升高较对照组显著（均P＜0.05）。结论柿叶提取物具有改善血压、血糖、血脂、血液流变性、血流动力学及抑制血小板聚集和血栓形成的作用。目的：探討柿葉提取物榦預治療對缺血性腦血管病患者二級預防的臨床療效，以及對缺血性腦血管病患者在血壓、血糖、血脂、血液流變學、血流速度、血同型半胱氨痠等指標水平的影響。方法選取2013年1月～2013年12月在武漢市東湖醫院就診的缺血性腦血管病患者200例，隨機分為對照組與觀察組各100例，對照組予以神經內科常規治療，觀察組在對照組基礎上給予柿葉提取物榦預治療，記錄比較2組治療前、治療3、6箇月後缺血性腦血管病的複髮率及血壓、血糖、血脂、血液流變學、血流速度、血同型半胱氨痠等指標水平。結果治療3月末，觀察組複髮率4.40％，對照組複髮率3.70％；治療6月末，觀察組複髮率8.24％，對照組複髮率13.75％，但2組比較差異均無統計學意義。2組治療6月末收縮壓、舒張壓比治療前下降，且觀察組下降較對照組顯著（均P＜0.05）。2組治療3、6月末與治療前比較，血清TC、TG、LDLC水平下降，HDLC水平升高；觀察組治療6月末上述指標變化較3月末顯著；治療6月末觀察組上述指標較對照組變化顯著（均P＜0.05）。2組治療3、6月末FBG、2hPG以及HbA1C較治療前下降顯著；2組治療6月末上述指標降低水平較3月末顯著；觀察組3、6月末上述指標下降較對照組同時點顯著（均P＜0.05）。2組治療3、6月末血清HCY水平較治療前下降顯著；觀察組治療3、6月末血清HCY水平較對照組同時點下降顯著（均P＜0.05）。2組治療6月末血液流變學各指標較治療前改善顯著；治療6月末觀察組血液流變學各指標較對照組改善顯著（均P＜0.05）。2組治療6月末腦部主要動脈血流速度均較治療前顯著升高；治療6月末觀察組與對照組腦部主要動脈血流速度變化升高較對照組顯著（均P＜0.05）。結論柿葉提取物具有改善血壓、血糖、血脂、血液流變性、血流動力學及抑製血小闆聚集和血栓形成的作用。
목적：탐토시협제취물간예치료대결혈성뇌혈관병환자이급예방적림상료효，이급대결혈성뇌혈관병환자재혈압、혈당、혈지、혈액류변학、혈류속도、혈동형반광안산등지표수평적영향。방법선취2013년1월～2013년12월재무한시동호의원취진적결혈성뇌혈관병환자200례，수궤분위대조조여관찰조각100례，대조조여이신경내과상규치료，관찰조재대조조기출상급여시협제취물간예치료，기록비교2조치료전、치료3、6개월후결혈성뇌혈관병적복발솔급혈압、혈당、혈지、혈액류변학、혈류속도、혈동형반광안산등지표수평。결과치료3월말，관찰조복발솔4.40％，대조조복발솔3.70％；치료6월말，관찰조복발솔8.24％，대조조복발솔13.75％，단2조비교차이균무통계학의의。2조치료6월말수축압、서장압비치료전하강，차관찰조하강교대조조현저（균P＜0.05）。2조치료3、6월말여치료전비교，혈청TC、TG、LDLC수평하강，HDLC수평승고；관찰조치료6월말상술지표변화교3월말현저；치료6월말관찰조상술지표교대조조변화현저（균P＜0.05）。2조치료3、6월말FBG、2hPG이급HbA1C교치료전하강현저；2조치료6월말상술지표강저수평교3월말현저；관찰조3、6월말상술지표하강교대조조동시점현저（균P＜0.05）。2조치료3、6월말혈청HCY수평교치료전하강현저；관찰조치료3、6월말혈청HCY수평교대조조동시점하강현저（균P＜0.05）。2조치료6월말혈액류변학각지표교치료전개선현저；치료6월말관찰조혈액류변학각지표교대조조개선현저（균P＜0.05）。2조치료6월말뇌부주요동맥혈류속도균교치료전현저승고；치료6월말관찰조여대조조뇌부주요동맥혈류속도변화승고교대조조현저（균P＜0.05）。결론시협제취물구유개선혈압、혈당、혈지、혈액류변성、혈류동역학급억제혈소판취집화혈전형성적작용。
Objective To investigate persimmon leaf extract on secondary prevention of ischemic cerebrovascular disease, and the impact on blood pressure, blood sugar, blood lipid, hemorheology, blood rheology indexes and blood homocysteine levels in patients with ischemic cerebrovascular disease.Methods 200 cases of patients with ischemic cerebral vascular disease were chosen, which were randomly divided into observation group and control group with 100 cases in each group.Both of the groups were given conventional therapy.And the observation group received persimmon leaf extract intervention.Then the rate of recurrence of ischemic cerebrovascular disease was observed after 3 months and 6 months.At the same time, the indexes of blood pressure and blood sugar, blood lipid, hemorheology, blood flow and blood homocysteine were recorded and compared in the second morning after being selected and after 3 months and 6 months treatment.Results After treatment for 3 months, the recurrence rate of observation group was 4.40%, 3.70% of control group; after treatment for 6 months, 8.24% of observation group, 13.75% of control group, and there were no significant differences between two groups of recurrence of ischemic cerebrovascular disease.After 6 months, systolic and diastolic blood pressure in both groups were lower than before treatment.and they were lower in observation group than control group (all P<0.05).After 3, 6 months, TC, TG, LDLC levels decreased and HDLC increased compared with before treatment, and the above indexes improved more in observation group than control group (all P<0.05).After 3, 6 months, FBG, 2hPG, HbA1C levels decreased compared with before treatment, and the above indexes decreased more at the same time point in observation group than control group (all P<0.05).After 3, 6 months, HCY levels decreased compared with before treatment, and HCY decreased more at the same time point in observation group than control group ( all P<0.05 ).After 6 months, blood rheology indexes levels improved more compared with before treatment, and they improved more at the same time point in observation group than control group (all P<0.05).After 6 months, main artery blood flow velocity levels increased compared with before treatment, and they increased more at the same time point in observation group than control group ( all P<0.05 ) .Conclusion Persimmon leaf extract intervention therapy can effectively improve blood pressure , sugar, lipid, hemorheology, homocysteine and prevent platelet aggregation and thrombosis.