实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
PRACTICAL JOURNAL OF CARDIAC CEREBRAL PNEUMAL AND VASCULAR DISEASE
2015年
3期
97-99
,共3页
吴学杰%薛明明%黄君龄%张亚平%王春兰%宋振举%陶振钢%姚晨玲%童朝阳%袁颖
吳學傑%薛明明%黃君齡%張亞平%王春蘭%宋振舉%陶振鋼%姚晨玲%童朝暘%袁穎
오학걸%설명명%황군령%장아평%왕춘란%송진거%도진강%요신령%동조양%원영
呼吸道感染%细菌感染%老年人%疏风解毒胶囊%抗菌药
呼吸道感染%細菌感染%老年人%疏風解毒膠囊%抗菌藥
호흡도감염%세균감염%노년인%소풍해독효낭%항균약
Respiratory tract infections%Bacterial infections%Aged%Shufeng jiedu capsule%Anti-bacterial agents
目的：观察疏风解毒胶囊联合抗生素治疗老年急性细菌性上呼吸道感染的临床疗效。方法选择2013—2014年上海市杨浦区中心医院急诊科诊治的老年急性细菌性上呼吸道感染患者231例，随机分为联合治疗组112例与对照组119例。在对症治疗基础上，对照组患者给予抗生素治疗，联合治疗组患者给予抗生素联合疏风解毒胶囊治疗，均治疗7 d。比较两组患者治疗第1、3天体温、白细胞计数、炎性细胞因子〔白介素1（IL-1）、白介素6（IL-6）、肿瘤坏死因子α（TNF-α）〕、降钙素原（PCT）及第3天体温恢复正常率。结果治疗第1天两组患者体温、白细胞计数及血清IL-1、IL-6、TNF-α、PCT水平比较，差异无统计学意义（ P>0.05）；治疗第3天联合治疗组患者体温、白细胞计数及血清IL-1、IL-6、TNF-α、PCT水平低于对照组（ P<0.05）。治疗第3天联合治疗组患者体温恢复正常率为88.4%，高于对照组的66.4%（P<0.05）。结论疏风解毒胶囊联合抗生素治疗老年急性细菌性上呼吸道感染疗效确切，能有效控制患者体温及炎症。临床试验注册号ChiCTR-TRC-14004695。
目的：觀察疏風解毒膠囊聯閤抗生素治療老年急性細菌性上呼吸道感染的臨床療效。方法選擇2013—2014年上海市楊浦區中心醫院急診科診治的老年急性細菌性上呼吸道感染患者231例，隨機分為聯閤治療組112例與對照組119例。在對癥治療基礎上，對照組患者給予抗生素治療，聯閤治療組患者給予抗生素聯閤疏風解毒膠囊治療，均治療7 d。比較兩組患者治療第1、3天體溫、白細胞計數、炎性細胞因子〔白介素1（IL-1）、白介素6（IL-6）、腫瘤壞死因子α（TNF-α）〕、降鈣素原（PCT）及第3天體溫恢複正常率。結果治療第1天兩組患者體溫、白細胞計數及血清IL-1、IL-6、TNF-α、PCT水平比較，差異無統計學意義（ P>0.05）；治療第3天聯閤治療組患者體溫、白細胞計數及血清IL-1、IL-6、TNF-α、PCT水平低于對照組（ P<0.05）。治療第3天聯閤治療組患者體溫恢複正常率為88.4%，高于對照組的66.4%（P<0.05）。結論疏風解毒膠囊聯閤抗生素治療老年急性細菌性上呼吸道感染療效確切，能有效控製患者體溫及炎癥。臨床試驗註冊號ChiCTR-TRC-14004695。
목적：관찰소풍해독효낭연합항생소치료노년급성세균성상호흡도감염적림상료효。방법선택2013—2014년상해시양포구중심의원급진과진치적노년급성세균성상호흡도감염환자231례，수궤분위연합치료조112례여대조조119례。재대증치료기출상，대조조환자급여항생소치료，연합치료조환자급여항생소연합소풍해독효낭치료，균치료7 d。비교량조환자치료제1、3천체온、백세포계수、염성세포인자〔백개소1（IL-1）、백개소6（IL-6）、종류배사인자α（TNF-α）〕、강개소원（PCT）급제3천체온회복정상솔。결과치료제1천량조환자체온、백세포계수급혈청IL-1、IL-6、TNF-α、PCT수평비교，차이무통계학의의（ P>0.05）；치료제3천연합치료조환자체온、백세포계수급혈청IL-1、IL-6、TNF-α、PCT수평저우대조조（ P<0.05）。치료제3천연합치료조환자체온회복정상솔위88.4%，고우대조조적66.4%（P<0.05）。결론소풍해독효낭연합항생소치료노년급성세균성상호흡도감염료효학절，능유효공제환자체온급염증。림상시험주책호ChiCTR-TRC-14004695。
Objective To observe the effect of shufeng jiedu capsule combined with antibiotics on aged patients with bacterial acute upper respiratory tract infection. Methods From 2013 to 2014,a total of 231 aged patients with bacterial acute upper respiratory tract infection were selected in the Centeral Hospital of Yangpu District,Shanghai,and they were randomly divided into control group ( n =119 ) and observation group ( n =112 ). Patients of both groups were given symptomatic treatment,and patients of control group were given antibiotics,patients of observation group were given shufeng jiedu capsule combined with antibiotics;both groups treated for 7 days. Body temperature,white blood cells count,serum levels of IL-1, IL-6,TNF-α,PCT were compared between the two groups after 1 day,3 days of treatment,and body temperature recovery rate was recorded after 3 days of treatment. Results No statistically significant differences of body temperature,white blood cells count,serum levels of IL-1,IL-6,TNF-α,PCT was found between the two groups after 1 day of treatment( P>0. 05);while above index of observation group were lower than those of control group after 3 days of treatment(P<0. 05). The body temperature recovery rate of observation group was 88. 4%,was higher than that of control group of 66. 4%(P<0. 05). Conclusion Shufeng jiedu capsule combined with antibiotics is certainly effective in treating aged patients with bacterial acute upper respiratory tract infection, can effectively control the body temperature and inflammation. Clinical trial registration number ChiCTR-TRC-14004695.
