CAJ | 학술논문

心律失常是心血管领域的常见病、多发病。2013年3月世界卫生组织报道，2008年死于心脑血管疾病者高达1730万，而到2030年将增至2330万。其中心脏性猝死占40%~50%，而大多数心脏性猝死由心律失常所引发，故抗心律失常新药的研发刻不容缓。近几年化学抗心律药物的研发渐入瓶颈，天然药物抗心律失常的价值重新得到世界的关注。目前天然药物抗心律失常活性成分多为生物碱类、黄酮类、皂苷类。本研究通过综合分析已报道的相关文献，概括近几年抗心律失常的天然药物活性成分研究进展，为天然药物活性成分的进一步研究提供依据。
심률실상시심혈관영역적상견병、다발병。2013년3월세계위생조직보도，2008년사우심뇌혈관질병자고체1730만，이도2030년장증지2330만。기중심장성졸사점40%~50%，이대다수심장성졸사유심률실상소인발，고항심률실상신약적연발각불용완。근궤년화학항심률약물적연발점입병경，천연약물항심률실상적개치중신득도세계적관주。목전천연약물항심률실상활성성분다위생물감류、황동류、조감류。본연구통과종합분석이보도적상관문헌，개괄근궤년항심률실상적천연약물활성성분연구진전，위천연약물활성성분적진일보연구제공의거。
Arrhythmias are common in the field of cardiovascular disease. In March 2013, World Health Organization reported that, in 2008 the population who died of cardiovascular disease has been as high as 17.3 million, and by 2030 will increase to 23.3 million. Sudden cardiac death accounts for about 40%-50%, while the majority of sudden cardiac death caused by arrhythmia, so the development of new drugs antiarrhythmic is urgent. In recent years, the development of chemical antiarrhythmic drugs getting into the bottleneck, the value of natural antiarrhythmic drug has gotten the world's attention again. At present, the active ingredient of natural antiarrhythmic drugs mainly are alkaloids, flavonoids, saponins. By a comprehensive analysis of the reported literature, the article generalizes the research progress which is about the active ingredient of natural antiarrhythmic drug in nearly a decade, in order to provide certain basis for further study on the active ingredient of natural drugs.