CAJ | 학술논문

本文将试图寻找结合与现代生物学技术的蒙药作用机制研究的新方法。根据目前的蒙药作用机制研究方法和现代药物研究方法的需求，整理微小核糖核酸(microRNA，miRNA)相关文献，分析miRNA在蒙药作用机制研究中的应用可能性。结果显示，miRNA不但可以作为治疗和蒙药干预的一类新的体内作用靶标，也可以作为蒙药的一种活性分子在蒙药作用机制研究中发挥作用。如果能够把miRNA相关技术充分应用于本领域，从技术开发的角度解决蒙药作用机制研究的实验设计关键之处与难点，既能够扩展miRNA本身的应用范围，又对蒙药现代化和走向世界具有重要意义。本研究提示和建议蒙药学研究领域学者对miRNA开展深入的验证实验，为蒙医药学的发展提供新的科学依据。
본문장시도심조결합여현대생물학기술적몽약작용궤제연구적신방법。근거목전적몽약작용궤제연구방법화현대약물연구방법적수구，정리미소핵당핵산(microRNA，miRNA)상관문헌，분석miRNA재몽약작용궤제연구중적응용가능성。결과현시，miRNA불단가이작위치료화몽약간예적일류신적체내작용파표，야가이작위몽약적일충활성분자재몽약작용궤제연구중발휘작용。여과능구파miRNA상관기술충분응용우본영역，종기술개발적각도해결몽약작용궤제연구적실험설계관건지처여난점，기능구확전miRNA본신적응용범위，우대몽약현대화화주향세계구유중요의의。본연구제시화건의몽약학연구영역학자대miRNA개전심입적험증실험，위몽의약학적발전제공신적과학의거。
This review summarizes the microRNA (miRNA) literatures, based on the method demands of both current studies on the mechanism of Mongolian medicine and modern medicine, analyzes the application possibility of miRNA on the research of the mechanism of Mongolian medicine, and explores a new research technique for studying the mechanism of Mongolian medicine, by combining modern biological technology. The results show that miRNA plays a critical role in the study of the mechanism of Mongolian medicine, not only as a new functional target for therapeutic, but also as an effective molecule of Mongolian medicine. It would expand the scope of miRNA application itself and of great importance for the modernization and globalization of Mongolian medicine, if miRNA-related technology can be sufficiently employed in this field, and resolve the key point and difficulties in the design of experiments. We advise more Mongolian medicine researchers to carry out further experiments of miRNAs to provide new scientific evidences for the development of Mongolian medicine.