CAJ | 학술논문

目的：分析吉兰巴雷综合征(GBS)急性期临床、电生理及脑脊液特点，并探讨其病情进展严重程度的相关因素。方法回顾性分析2000年10月~2014年10月于长海医院就诊的GBS患者113例，根据患者高峰期Hughes评分划分病情等级，用Logistic回归模型分析病情严重程度与临床、电生理及脑脊液指标的相关性。结果急性期GBS患者年龄≥50岁(P=0.034，OR =14.702，95%CI：1.228~175.982)、脑脊液IgG增高(P=0.028，OR =26.652，95%CI：1.438~493.791)、周围神经轴索损害为主者(P=0.037，OR =48.529，95%CI：1.273~1850.656)更易发展为重型GBS。结论存在年龄≥50岁、脑脊液IgG增高、周围神经轴索损害的GBS患者病情相对较重，临床医生应针对此类患者提前实现个体化治疗。
목적：분석길란파뢰종합정(GBS)급성기림상、전생리급뇌척액특점，병탐토기병정진전엄중정도적상관인소。방법회고성분석2000년10월~2014년10월우장해의원취진적GBS환자113례，근거환자고봉기Hughes평분화분병정등급，용Logistic회귀모형분석병정엄중정도여림상、전생리급뇌척액지표적상관성。결과급성기GBS환자년령≥50세(P=0.034，OR =14.702，95%CI：1.228~175.982)、뇌척액IgG증고(P=0.028，OR =26.652，95%CI：1.438~493.791)、주위신경축색손해위주자(P=0.037，OR =48.529，95%CI：1.273~1850.656)경역발전위중형GBS。결론존재년령≥50세、뇌척액IgG증고、주위신경축색손해적GBS환자병정상대교중，림상의생응침대차류환자제전실현개체화치료。
Objective To analyze the clinical, electrophysiological and cerebrospinal characteristics of Guillain-Barre syndrome (GBS) during acute phase, and to explore the relevant factors of severity of progressive disease. Methods 113 patients with GBS admitted to Changhai Hospital from October 2000 to October 2014 were analyzed retrospectively. Hughes scale of fastigium was used to divide the illness level. Logistic regression model was used to analyze the corre-lation of severty of illness with clinical, electrophysiological and cerebrospinal indexes. Results Among the patients with GBS during acute phase, those whose age≥50 years old (P= 0.034, OR = 14.702, 95%CI: 1.228-175.982), in-crease of immunoglobulin G in cerebrospinal fluid (P=0.028, OR =26.652, 95%CI: 1.438-493.791), peripheral nerve neuraxon impairment (P=0.037, OR = 48.529, 95%CI: 1.273-1850.656) were more likely to develop as severe GBS. Conclusion The state of patients with age≥50 years old, increase of immunoglobulin G in cerebrospinal fluid, periph-eral nerve neuraxon impairment is more severe. Clinical doctors should realize individualized treatment in advance aiming at such patients.