CAJ | 학술논문

目的：分析白细胞介素4(IL-4)rs2070874,白细胞介素10(IL-10)rs1800871、rs1800872基因型及其基因频率在汉族成年胃癌患者与正常对照人群中的分布情况,探讨 IL-4,IL-10基因多态性与胃癌临床易感性的关系。方法病例组胃癌患者84例,正常对照组105例,两组均留取外周静脉血提取 DNA,利用直接测序法对 IL-4 rs2070874,IL-10 rs1800871、rs1800872进行基因型测定,分析各位点多态性与胃癌临床易感性关系。结果 IL-4 rs2070874基因多态性在病例组与对照组等位基因之间、基因型之间的分布差异有统计学意义(P <0.05)；IL-10 rs1800871、rs1800872基因多态性在病例组与对照组等位基因之间、基因型之间的分布差异无统计学意义(P >0.05)。结论 IL-4 rs2070874基因多态性与胃癌感染易感性有关,而 IL-10 rs1800871、rs1800872位点基因多态性与胃癌易感性可能不相关。
목적：분석백세포개소4(IL-4)rs2070874,백세포개소10(IL-10)rs1800871、rs1800872기인형급기기인빈솔재한족성년위암환자여정상대조인군중적분포정황,탐토 IL-4,IL-10기인다태성여위암림상역감성적관계。방법병례조위암환자84례,정상대조조105례,량조균류취외주정맥혈제취 DNA,이용직접측서법대 IL-4 rs2070874,IL-10 rs1800871、rs1800872진행기인형측정,분석각위점다태성여위암림상역감성관계。결과 IL-4 rs2070874기인다태성재병례조여대조조등위기인지간、기인형지간적분포차이유통계학의의(P <0.05)；IL-10 rs1800871、rs1800872기인다태성재병례조여대조조등위기인지간、기인형지간적분포차이무통계학의의(P >0.05)。결론 IL-4 rs2070874기인다태성여위암감염역감성유관,이 IL-10 rs1800871、rs1800872위점기인다태성여위암역감성가능불상관。
Objective To investigate the relationship between IL-10, IL-4 gene polymorphisms and susceptibility of gastric cancer,also to analyze the distribution of genotype and gene frequency of IL-4 rs2070874,IL-10 rs1800871 and IL-10 rs1800872 in gastric cancer patients and normal control group in Han population.Methods Eighty-four gastric cancer patients and 105 control cases were included in this study.Peripheral venous blood was extracted to obtain DNA.Genotype of IL-4 rs2070874,IL-10 rs1800871 and IL-10 rs1800872 were detected by direct sequencing method.Results IL-4 rs2070874 gene polymorphism was significantly different between two groups (P <0.05 ),no significant difference were found in IL-10 rs1800871 and rs1800872 gene polymorphisms between two groups (P > 0.05 ).Conclusion IL-4 rs2070874 gene polymorphism was associated with susceptibility of gastric cancer, whereas IL-10 rs1800871 and rs1800872 gene polymorphisms may not be related to the susceptibility of gastric cancer.