临床荟萃
臨床薈萃
림상회췌
CLINICAL FOCUS
2015年
5期
517-520
,共4页
胃肿瘤%病理学%miR-129%基因表达调控
胃腫瘤%病理學%miR-129%基因錶達調控
위종류%병이학%miR-129%기인표체조공
stomach neoplasms%pathology%miR-129%gene expression regulation
目的：探讨 microRNA129(简称 miR129)在胃管状腺瘤、胃脉癌组织及其对应的癌旁组织中的表达及其临床意义。方法收集病理确诊的55例管状腺瘤、76例胃腺癌组织及对应的癌旁组织，分别用原位杂交方法检测miR129的表达，分析 miR129表达与临床病理参数之间的关系。结果癌旁胃黏膜组织中 miR-129的表达阳性率高于胃管状腺瘤组织，胃管状腺瘤组织中 miR-129的表达阳性率高于胃腺癌组织(P <0.05)。miR129在高分化胃癌组织中阳性表达率高于中、低分化组织(P <0.05)；临床分期Ⅰ中的阳性表达率高于Ⅲ期；无淋巴结转移组织中的表达阳性率高于有淋巴结转移组织(P <0.05)；胃管状腺癌中 miR129阳性率高于弥漫型腺癌(P <0.05)。结论miR129在胃腺癌组织内低表达，发挥着抑癌基因的作用；miR129可作为胃腺癌的判断预后的标志物。
目的：探討 microRNA129(簡稱 miR129)在胃管狀腺瘤、胃脈癌組織及其對應的癌徬組織中的錶達及其臨床意義。方法收集病理確診的55例管狀腺瘤、76例胃腺癌組織及對應的癌徬組織，分彆用原位雜交方法檢測miR129的錶達，分析 miR129錶達與臨床病理參數之間的關繫。結果癌徬胃黏膜組織中 miR-129的錶達暘性率高于胃管狀腺瘤組織，胃管狀腺瘤組織中 miR-129的錶達暘性率高于胃腺癌組織(P <0.05)。miR129在高分化胃癌組織中暘性錶達率高于中、低分化組織(P <0.05)；臨床分期Ⅰ中的暘性錶達率高于Ⅲ期；無淋巴結轉移組織中的錶達暘性率高于有淋巴結轉移組織(P <0.05)；胃管狀腺癌中 miR129暘性率高于瀰漫型腺癌(P <0.05)。結論miR129在胃腺癌組織內低錶達，髮揮著抑癌基因的作用；miR129可作為胃腺癌的判斷預後的標誌物。
목적：탐토 microRNA129(간칭 miR129)재위관상선류、위맥암조직급기대응적암방조직중적표체급기림상의의。방법수집병리학진적55례관상선류、76례위선암조직급대응적암방조직，분별용원위잡교방법검측miR129적표체，분석 miR129표체여림상병리삼수지간적관계。결과암방위점막조직중 miR-129적표체양성솔고우위관상선류조직，위관상선류조직중 miR-129적표체양성솔고우위선암조직(P <0.05)。miR129재고분화위암조직중양성표체솔고우중、저분화조직(P <0.05)；림상분기Ⅰ중적양성표체솔고우Ⅲ기；무림파결전이조직중적표체양성솔고우유림파결전이조직(P <0.05)；위관상선암중 miR129양성솔고우미만형선암(P <0.05)。결론miR129재위선암조직내저표체，발휘착억암기인적작용；miR129가작위위선암적판단예후적표지물。
Objective To investigate the expression of miR129 in stomach tubular adenoma,adenocarcinoma and its matched adjacent non-neoplastic tissure for its significance.Methods Fifty-five cases with gastric tubular adenoma,76 cases with gastric adenocarcinoma and matched para-carcinoma tissues were selected into this experiment. Hybridization in situ was carried out to detect the miR-129 expression,and correlation between miR129 and clinical features was analyzed.Results The positive rate of miR-129 expression in para-carcinoma mucosa was significantly higher than that of gastric adenoma,and the positive rate of miR-129 expression in stomach tubular adenoma was significantly higher than that of adenocarcinoma (P <0.05).The positive expression rate of miR-129 in grade Ⅰ was significantly higher than that in grade Ⅱ and Ⅲ (P <0.05);the positive rate of miR-129 in stage Ⅰ was significantly higher than that in stage Ⅱ and Ⅲ (P < 0.05 );the positive rate of miR-129 in the cases without lymphonode metastasis was significantly higher than that of the cases with lymphonode metastasis (P < 0.05 );the positive expression rate of miR-129 in the cases with intestinal type carcinoma was significantly higher than that of the cases with diffuse type (P <0.05).Conclusion Expression of miR129 was down-regulated in gastric adenocarcinoma and it played a role as anti-oncogene;miR129 may act as a promising prognostic biomarker for gastric adenocarcinoma.
