CAJ | 학술논문

目的：探讨KAI1/CD82在人脑胶质瘤中的表达及其与恶性程度的关系。方法收集脑胶质瘤病理132例，为胶质瘤组，对照组为20例颅脑外伤内减压的脑组织，按照胶质瘤级别胶质瘤组分为四个亚组。采用免疫组化方法分析胶质瘤组与对照组间，以及不同恶性程度胶质瘤中KAI1/CD82基因表达。结果KAI1/CD82在胶质瘤组中表达率显著高于对照组(P<0.05)。不同恶性程度胶质瘤中KAI1/CD82的表达差异有统计学意义(P<0.05)。 KAI1/CD82的表达与人脑胶质瘤的恶性程度呈正相关，在Ⅲ-Ⅳ级胶质瘤中表达明显高于Ⅰ-Ⅱ级胶质瘤(P<0.05)。通过随访发现KAI1/CD82阳性组复发率低于阴性组，两组比较差异有统计学意义(P<0.05)。结论 KAI1/CD82在胶质瘤的发生和发展中起着重要作用。检测KAI1/CD82的表达可能成为监测胶质瘤进展及临床上判断预后的重要参考指标。
목적：탐토KAI1/CD82재인뇌효질류중적표체급기여악성정도적관계。방법수집뇌효질류병리132례，위효질류조，대조조위20례로뇌외상내감압적뇌조직，안조효질류급별효질류조분위사개아조。채용면역조화방법분석효질류조여대조조간，이급불동악성정도효질류중KAI1/CD82기인표체。결과KAI1/CD82재효질류조중표체솔현저고우대조조(P<0.05)。불동악성정도효질류중KAI1/CD82적표체차이유통계학의의(P<0.05)。 KAI1/CD82적표체여인뇌효질류적악성정도정정상관，재Ⅲ-Ⅳ급효질류중표체명현고우Ⅰ-Ⅱ급효질류(P<0.05)。통과수방발현KAI1/CD82양성조복발솔저우음성조，량조비교차이유통계학의의(P<0.05)。결론 KAI1/CD82재효질류적발생화발전중기착중요작용。검측KAI1/CD82적표체가능성위감측효질류진전급림상상판단예후적중요삼고지표。
Objective To study the expression of KAI1/CD82 in human brain glioma and its relationship with malignant degrees. Methods Gene expression of KAI1/CD82 levels were studied using immunohistochemical methods in 132 cases with different degrees of malignant glioma. Results the expression of KAI1/CD82 had significant difference in different degrees of malignant glioma (P<0.05). The expression of KAI1/CD82 positively correlated with the malignant degree of brain glioma, and expression inⅢ-Ⅳ grade glioma was significantly higher thanⅠ-Ⅱgrade glioma (P<0.05). Followed-up, the recurrence rate in KAI1/CD82positive patients is significant lower than the negative group (P<0.05). Conclusion KAI1/CD82 plays an important role in the occurrence and development of glioma. To detect the expression of KAI1/CD82 may be an important indicator to monitor the progress and prognosis of glioma.