CAJ | 학술논문

目的：探讨长春新碱联合甲基泼尼松龙治疗系统性红斑狼疮并血小板减少症的疗效，为临床治疗提供依据。方法选取系统性红斑狼疮并血小板减少症患者78例，随机分为对照组和治疗组各39例，对照组应用甲基泼尼松龙大剂量冲击治疗，治疗组应用长春新碱联合甲基泼尼松龙治疗，进行疗效比较观察。结果治疗组 CR25例(64.10%)，PR 10例(25.64%)， NR 4例(10.26%)，总有效率(CR+PR)89.74%；对照组CR19例(48.72%)，PR 7例(17.95%)，NR 13例(33.33%)，总有效率(CR+PR)66.66%。两组数据比较，总有效率(CR+PR)χ2检验，χ2为3.343，P=0.032，*P<0.05，说明经统计学处理差异有显著性。结论应用长春新碱联合甲基泼尼松龙治疗系统性红斑狼疮并血小板减少症，不仅可以提高治疗效果，减少出血，而且可以改善和提高患者的生活质量，值得临床推广应用。
목적：탐토장춘신감연합갑기발니송룡치료계통성홍반랑창병혈소판감소증적료효，위림상치료제공의거。방법선취계통성홍반랑창병혈소판감소증환자78례，수궤분위대조조화치료조각39례，대조조응용갑기발니송룡대제량충격치료，치료조응용장춘신감연합갑기발니송룡치료，진행료효비교관찰。결과치료조 CR25례(64.10%)，PR 10례(25.64%)， NR 4례(10.26%)，총유효솔(CR+PR)89.74%；대조조CR19례(48.72%)，PR 7례(17.95%)，NR 13례(33.33%)，총유효솔(CR+PR)66.66%。량조수거비교，총유효솔(CR+PR)χ2검험，χ2위3.343，P=0.032，*P<0.05，설명경통계학처리차이유현저성。결론응용장춘신감연합갑기발니송룡치료계통성홍반랑창병혈소판감소증，불부가이제고치료효과，감소출혈，이차가이개선화제고환자적생활질량，치득림상추엄응용。
O bjective Discussion the effect of vincristine and methyl prednisolone treatment of systemic lupus erythematosus and thrombocytopenia , provide the basis for clinical treatment. Methods Selected 78 patients with systemic lupus erythematosus and thrombocytopenia, were randomly divided into a control group and the treatment group , 39 patients in the control group with high-dose methylprednisolone pulse therapy , treatment group and methyl prednisolone, vincristine, efficacy comparison observation. Results CR 25 cases treatment group (64.10%), PR 10 cases (25.64%), NR 4 cases (10.26%), the total effective rate (CR+PR) 89.74%. CR19cases control group (48.72%), PR 7 cases(17.95%), NR 13 cases(33.33%), the total effective rate (CR+PR)66.66%. Compare two sets of data , the total efficiency(CR+PR) chi-square test ,χ2=3.343, P=0.032,*P<0.05, explain differences were sta-tistically significant. Conclusion vincristine and methyl prednisolone treatment of Systemic lupus erythematosus and thrombocy-topenia , not only can improve the therapeutic effect and reduce Bleeding, and can improve and enhance the quality of life of pa-tients , worthy of clinical application.