CAJ | 학술논문

目的：探究疏血通治疗冠心病心绞痛的疗效及安全性与用药剂量的关系。方法选取该院从2013年10月—2014年8月份收治的67例冠心病心绞痛患者作为研究的对象，并随机分为A(n=33)和B组(n=34)。在常规治疗基础之上，A组给予6 mL疏血通治疗，B组给予10 mL疏血通治疗，比较两组临床效果和副作用。结果治疗后，B组心绞痛症状改善总有效率为94.1%，明显高于A组72.7%(χ2=5.584，P=0.018)；B组心电图改善总有效率为88.2%，明显高于A组的66.7%(χ2=4.484，P=0.034)；A组合B两组均未发现明显不良反应。结论疏血通可安全有效地治疗冠心病心绞痛，且在安全用药范围内，较大剂量临床效果更佳。
목적：탐구소혈통치료관심병심교통적료효급안전성여용약제량적관계。방법선취해원종2013년10월—2014년8월빈수치적67례관심병심교통환자작위연구적대상，병수궤분위A(n=33)화B조(n=34)。재상규치료기출지상，A조급여6 mL소혈통치료，B조급여10 mL소혈통치료，비교량조림상효과화부작용。결과치료후，B조심교통증상개선총유효솔위94.1%，명현고우A조72.7%(χ2=5.584，P=0.018)；B조심전도개선총유효솔위88.2%，명현고우A조적66.7%(χ2=4.484，P=0.034)；A조합B량조균미발현명현불량반응。결론소혈통가안전유효지치료관심병심교통，차재안전용약범위내，교대제량림상효과경가。
Objective To investigate effect and its safety of different doses of Shuxuetong Injection on angina pectoris of coronary heart disease.Methods 67 cases with angina pectoris of coronary heart disease from 2013 October to 2014 August in our hospital were selected as the research object,and were randomly divided into A group (n=33) and B group (n=34). On the basis of routine treatment, A group were given 6mL of Shuxuetong treatment, while B group were given 10mL of Shuxuetong treatment. Results Af-ter treatment, the total efficiency of angina symptoms improving of B group was 94.1%, which was significantly higher than that of the A group 72.7%(χ2=5.584,P=0.018).The total efficiency of ECG improving of B group was 88.2%, which was significantly high-er than that of the A group 66.7%(χ2=4.484,P=0.034). Two groups were no obvious adverse reaction. Conclusion Shuxuetong injec-tion is safe and effective for the treatment of angina pectoris of coronary heart disease, and large dose of clinical effect is better in the medication safety range.