暨南大学学报（自然科学与医学版）
暨南大學學報（自然科學與醫學版）
기남대학학보（자연과학여의학판）
JOURNAL OF JINAN UNIVERSITY（NATURAL SCIENCE & MEDICINE EDITION）
2015年
2期
174-177
,共4页
心力衰竭%糖类抗原 125%预后评估
心力衰竭%糖類抗原 125%預後評估
심력쇠갈%당류항원 125%예후평고
heart failure%carbohydrate antigen125%prognosis
目的：探讨血清糖类抗原125（CA125）测定对心力衰竭患者预后评估的价值．方法：201例心衰患者根据纽约心脏学会（NYHA）心功能分级标准分为Ⅱ级、Ⅲ级、Ⅳ级，入院24 h 内测定血清 CA125和血浆脑钠肽（BNP）浓度，将患者分为高 CA125组（CA125≥35 U ／mL）和正常 CA125组（CA125＜35 U ／mL），比较两组患者住院死亡率；随访12±6个月，比较两组患者死亡率及再住院率；运用多因素 logistic 回归分析死亡相关因素．结果：两组患者的 NYHA 分级、超声心动图参数（左心房内径、左心室舒张末内径、左心室射血分数）、血浆 B 型尿钠肽（BNP）水平有显著性差别；高 CA125组住院死亡率为20.0％，正常 CA125组住院死亡率为3.1％，P ＝0.000；随访12±6个月，两组死亡率分别为22.9％和4.6％，再住院率分别为21.3％和3.8％；多因素 logistic 回归分析提示 CA125是心衰患者死亡独立危险因素，OR ＝2.257，P ＝0.030．结论：CA125是心力衰竭患者预后的独立危险因素，对心力衰竭患者的预后评估有一定价值．
目的：探討血清糖類抗原125（CA125）測定對心力衰竭患者預後評估的價值．方法：201例心衰患者根據紐約心髒學會（NYHA）心功能分級標準分為Ⅱ級、Ⅲ級、Ⅳ級，入院24 h 內測定血清 CA125和血漿腦鈉肽（BNP）濃度，將患者分為高 CA125組（CA125≥35 U ／mL）和正常 CA125組（CA125＜35 U ／mL），比較兩組患者住院死亡率；隨訪12±6箇月，比較兩組患者死亡率及再住院率；運用多因素 logistic 迴歸分析死亡相關因素．結果：兩組患者的 NYHA 分級、超聲心動圖參數（左心房內徑、左心室舒張末內徑、左心室射血分數）、血漿 B 型尿鈉肽（BNP）水平有顯著性差彆；高 CA125組住院死亡率為20.0％，正常 CA125組住院死亡率為3.1％，P ＝0.000；隨訪12±6箇月，兩組死亡率分彆為22.9％和4.6％，再住院率分彆為21.3％和3.8％；多因素 logistic 迴歸分析提示 CA125是心衰患者死亡獨立危險因素，OR ＝2.257，P ＝0.030．結論：CA125是心力衰竭患者預後的獨立危險因素，對心力衰竭患者的預後評估有一定價值．
목적：탐토혈청당류항원125（CA125）측정대심력쇠갈환자예후평고적개치．방법：201례심쇠환자근거뉴약심장학회（NYHA）심공능분급표준분위Ⅱ급、Ⅲ급、Ⅳ급，입원24 h 내측정혈청 CA125화혈장뇌납태（BNP）농도，장환자분위고 CA125조（CA125≥35 U ／mL）화정상 CA125조（CA125＜35 U ／mL），비교량조환자주원사망솔；수방12±6개월，비교량조환자사망솔급재주원솔；운용다인소 logistic 회귀분석사망상관인소．결과：량조환자적 NYHA 분급、초성심동도삼수（좌심방내경、좌심실서장말내경、좌심실사혈분수）、혈장 B 형뇨납태（BNP）수평유현저성차별；고 CA125조주원사망솔위20.0％，정상 CA125조주원사망솔위3.1％，P ＝0.000；수방12±6개월，량조사망솔분별위22.9％화4.6％，재주원솔분별위21.3％화3.8％；다인소 logistic 회귀분석제시 CA125시심쇠환자사망독립위험인소，OR ＝2.257，P ＝0.030．결론：CA125시심력쇠갈환자예후적독립위험인소，대심력쇠갈환자적예후평고유일정개치．
Aim:To investigate the prognostic value of carbohydrate antigen125(CA125)in heart fail-ure patients.Methods:Two hundred and one heart failure patients were divided into three groups,grade II、grade Ⅲ and grade Ⅳ according to the criterion of NYHA,Their serum concentration of CA125 and plasma concentration of BNP obtained within 24hrs after admission,were divided into two groups accord-ing to CA125 levels,elevated (≥35 U /mL)and normal (CA125 <35 U /mL).Mortalities in hospital as well as Mortalities and hospitalizations within 12 ±6 months after discharge were compared,Multivariate logistic regression analysis was also done.Results:Two groups were significantly different regarding NY-HA class、echocardiography parameters(LA、LVEDD、LVEF)and BNP level.In hospital,mortality of el-evated group was 20.0% and normal group was 3.1%,P =0.000.12 ±6 months follow-up,mortalities of two groups were 22.9% and 4.6%,rehospitalizations were 21.3% and 3.8% respectively.Multivari-ate regression analysis showed that CA125 was independent predictor of mortality,OR =2.257,P =0.030.Conclusion:CA125 is an independent stratification factor of heart failure.CA125 can provide ad-ditional prognostic value for heart failure patients.
