CAJ | 학술논문

目的：研究个体化诊疗方案的依从性与疾病进展的相关性。方法入组的所有患者在初次就诊时制定帕金森病(PD)的个体化诊疗方案,并要求患者每隔3个月来医院复诊1次,对该患者的个体化治疗方案进行调整。将患者分为3组(第1组：每隔3个月复诊；第2组：每隔6个月复诊；第3组：每隔12个月复诊),患者在初诊时(OM),6个月复诊时(6M),12个月复诊时(12M)应用 Hoehn-Yahr 分级,UPDRS 量表,Schwab 量表对患者进行评分。结果复诊频率不同的3组 Hoehn-Yahr 分级的比较差异无统计学意义(P >0.05)；3组在初诊时的 UPDRS 量表、Schwab 量表的评分与12个月复诊时的评分比较差异有统计学意义(P <0.01)。结论系统规范的个体化诊疗方案可以延缓 PD 疾病的进展,并改善日常生活活动,延长患者独立生活的时间,从而提高患者的生活质量。
목적：연구개체화진료방안적의종성여질병진전적상관성。방법입조적소유환자재초차취진시제정파금삼병(PD)적개체화진료방안,병요구환자매격3개월래의원복진1차,대해환자적개체화치료방안진행조정。장환자분위3조(제1조：매격3개월복진；제2조：매격6개월복진；제3조：매격12개월복진),환자재초진시(OM),6개월복진시(6M),12개월복진시(12M)응용 Hoehn-Yahr 분급,UPDRS 량표,Schwab 량표대환자진행평분。결과복진빈솔불동적3조 Hoehn-Yahr 분급적비교차이무통계학의의(P >0.05)；3조재초진시적 UPDRS 량표、Schwab 량표적평분여12개월복진시적평분비교차이유통계학의의(P <0.01)。결론계통규범적개체화진료방안가이연완 PD 질병적진전,병개선일상생활활동,연장환자독립생활적시간,종이제고환자적생활질량。
Objective To explore the correlation of individualized treatment compliance and disease progression in Parkinson disease(PD).Methods Individualized treatment strategy was made for the patients in this study in the first visit,each patient should come back to visit every three months and treatment program will be adjusted based on disease situation.All patients were divided into three groups (Group 1:return visit every 3 months;Group 2:return visit every 6 months;Group 3:return visit every 12 months).Patients will be evaluated in the first visit after 6 months and after 12 months by Hoehn-Yahr scale,UPDRS scale and Schwab scale.Results There were no significant difference in Hoehn-Yahr grade among three groups (P >0.05).There were significant differences in the rating score evaluated by UPDRS scale and Schwab scale between return visit in the first time and return visit after 12 months among three groups (P < 0.01 ).Conclusion The systematical and normative individual treatment could delay the disease progression,prolong the time of independent activity,improve activities of daily life and the life quality of the patients.