CAJ | 학술논문

目的：探讨不同介入时窗和疗程对高压氧治疗急性脊髓损伤的影响。方法该院于2011年2月—2014年2月收治的急性脊髓损伤患者120例都给予基础治疗结合高压氧治疗，按计量变量分别进行描述性统计分析，计量变量有：术后高压氧开始治疗时间、术后高压氧治疗次数。结果术后3 d内与术后>3 d接受高压氧治疗患者治疗后的总有效率分别为95.0%和85.0%，术后高压氧治疗次数≤30 d与治疗次数>30 d的患者治疗后的总有效率分别为86.7%和96.7%。治疗前各变量组的血清IL-6和TNF-α表达量对比差异无统计学意义，术后3 d内接受高压氧治疗的血清IL-6和TNF-α表达量明显低术后>3 d接受高压氧治疗患者，术后高压氧治疗次数>30 d患者的血清IL-6和TNF-α表达量明显低术后治疗次数≤30 d患者(P<0.05)。结论早期长疗程高压氧辅助治疗急性脊髓损伤能抑制通过抑制炎症因子的释放实现提高治疗效果的目的，值得推广应用。
목적：탐토불동개입시창화료정대고압양치료급성척수손상적영향。방법해원우2011년2월—2014년2월수치적급성척수손상환자120례도급여기출치료결합고압양치료，안계량변량분별진행묘술성통계분석，계량변량유：술후고압양개시치료시간、술후고압양치료차수。결과술후3 d내여술후>3 d접수고압양치료환자치료후적총유효솔분별위95.0%화85.0%，술후고압양치료차수≤30 d여치료차수>30 d적환자치료후적총유효솔분별위86.7%화96.7%。치료전각변량조적혈청IL-6화TNF-α표체량대비차이무통계학의의，술후3 d내접수고압양치료적혈청IL-6화TNF-α표체량명현저술후>3 d접수고압양치료환자，술후고압양치료차수>30 d환자적혈청IL-6화TNF-α표체량명현저술후치료차수≤30 d환자(P<0.05)。결론조기장료정고압양보조치료급성척수손상능억제통과억제염증인자적석방실현제고치료효과적목적，치득추엄응용。
Objective To investigate the effects of different timing intervention of hyperbaric oxygen for treating acute spinal cord injury. Methods The hospital from 2011 February to 2014 February were analyzed 120 patients with acute spinal cord injury in accordance with the principles of the random draw were equally divided for the treatment group and control group, all patients were given basic treatment combined with hyperbaric oxygen therapy, but the treatment group were given the treatment within 3 days after injury, the control group were given the treatment after injury 3 days. Results After treatment, theresponse rates of the treatment group and the control group were 96.7%and 85.0%respectively that the treatmentgroup had significantly higher efficien-cy (P<0.05). The serum IL-6 and TNF-αexpression compared differences between the two groups were not statistically significant before treatment, and the serum IL-6 and TNF-αexpression of the treatment group were significantly lower than the control group after treatment(P<0.05). Conclusion Early hyperbaric oxygen adjunctive therapy in acute spinal cord injury can inhibit the release of inflammatory cytokines so as to achieve the purpose of improving the therapeutic effect that should be widely applied.