CAJ | 학술논문

目的：观察妊娠相关蛋白 A(PAPP-A)、尿转铁蛋白、D-二聚体在妊娠期高血压疾病患者检测中的意义及其相关性分析。方法选择在我院就诊的妊娠期高血压疾病患者120例,为妊娠期高血压疾病组,选择同期足月妊娠的健康孕妇30例,为正常妊娠组,选择健康体检的非孕期妇女20例,为健康对照组。观察3组的 PAPP-A,尿转铁蛋白和 D-二聚体水平及与妊娠期高血压疾病严重程度的关系及其相互关系。结果 PAPP-A、尿转铁蛋白和 D-二聚体水平在妊娠期高血压疾病组明显高于正常妊娠组和健康对照组(P <0.01),而正常妊娠组明显高于健康对照组(P <0.01)。PAPP-A、尿转铁蛋白和 D-二聚体水平随着妊娠期高血压疾病严重程度升高而升高(P <0.01)。妊娠期高血压疾病患者的 PAPP-A 水平与尿转铁蛋白(r =0.593,P <0.01)和 D-二聚体(r =0.692,P <0.01)呈正相关,而 D-二聚体与尿转铁蛋白呈正相关(r =0.622,P <0.01)。结论妊娠相关蛋白 A,尿转铁蛋白,D-二聚体水平的异常与妊娠期高血压疾病的严重程度有关,为早期诊断和治疗妊娠期高血压疾病提供了依据。
목적：관찰임신상관단백 A(PAPP-A)、뇨전철단백、D-이취체재임신기고혈압질병환자검측중적의의급기상관성분석。방법선택재아원취진적임신기고혈압질병환자120례,위임신기고혈압질병조,선택동기족월임신적건강잉부30례,위정상임신조,선택건강체검적비잉기부녀20례,위건강대조조。관찰3조적 PAPP-A,뇨전철단백화 D-이취체수평급여임신기고혈압질병엄중정도적관계급기상호관계。결과 PAPP-A、뇨전철단백화 D-이취체수평재임신기고혈압질병조명현고우정상임신조화건강대조조(P <0.01),이정상임신조명현고우건강대조조(P <0.01)。PAPP-A、뇨전철단백화 D-이취체수평수착임신기고혈압질병엄중정도승고이승고(P <0.01)。임신기고혈압질병환자적 PAPP-A 수평여뇨전철단백(r =0.593,P <0.01)화 D-이취체(r =0.692,P <0.01)정정상관,이 D-이취체여뇨전철단백정정상관(r =0.622,P <0.01)。결론임신상관단백 A,뇨전철단백,D-이취체수평적이상여임신기고혈압질병적엄중정도유관,위조기진단화치료임신기고혈압질병제공료의거。
Objective To observe the significance of pregnancy-associated protein A (PAPP-A ), urinary transferrin,D-dimer in patients with hypertension in pregnancy and their correlation.Methods The study enrolled 120 patients with pregnancy-induced hypertension syndrome as pregnancy-induced hypertension group,at the same period, 30 healthy pregnant women with a full-term pregnancy were selected as the normal pregnancy group and 20 non-pregnant healthy women were as the healthy control group.The levels of PAPP-A,urinary transferrin and D-dimer were observed in pregnancy-induced hypertension group,normal pregnancy group and healthy control group,their levels and disease severity were detected in pregnancy-induced hypertension group and their relationship was explored. Results The levels of PAPP-A,urinary transferrin and D-dimer in pregnancy-induced hypertension group were significantly higher than those of normal pregnancy group and healthy control group (P < 0.01 ),and the levels in normal pregnancy group were also higher compared with those of healthy control group (P <0.01),as the severity of pregnancy-induced hypertension increased,the levels of PAPP-A,urinary transferrin and D-dimer increased (P <0.01).There were positive correlation between PAPP-A and urinary transferrin (r =0.593,P <0.01)or D-dimer (r=0.692,P <0.01),while there were positive correlation between D-dimer and urinary transferrin (r =0.622,P <0.01).Conclusion There are of great significances between the severity of pregnancy-induced hypertension and levels of PAPP-A,urinary transferrin,D-dimmer,and the items can be provided for the early diagnosis and treatment of pregnancy-induced hypertension.