CAJ | 학술논문

目的：探讨褪黑素受体基因1B(melatonin receptor 1B,MTNR1B)rs10830963位点基因多态性与甘肃保安族人群2型糖尿病(T2DM)易感性的关系。方法采用病例对照研究方法,应用基质辅助激光解析电离飞行时间质谱技术(MALDI-TOF MS),检测保安族 T2DM 患者 MTNR1B 基因 rs10830963位点的基因型和等位基因的分布。结果 MTNR1B 基因 rs10830963位点多态性在 T2DM 组和对照组之间差异无统计学意义,G 等位基因的分布频率在两组中大致相同,分别为42.0%,38.6%(χ2=1.350,P >0.05)。结论 MTNR1B 基因 rs10830963位点可能不是甘肃保安族人群 T2DM 的易感基因。
목적：탐토퇴흑소수체기인1B(melatonin receptor 1B,MTNR1B)rs10830963위점기인다태성여감숙보안족인군2형당뇨병(T2DM)역감성적관계。방법채용병례대조연구방법,응용기질보조격광해석전리비행시간질보기술(MALDI-TOF MS),검측보안족 T2DM 환자 MTNR1B 기인 rs10830963위점적기인형화등위기인적분포。결과 MTNR1B 기인 rs10830963위점다태성재 T2DM 조화대조조지간차이무통계학의의,G 등위기인적분포빈솔재량조중대치상동,분별위42.0%,38.6%(χ2=1.350,P >0.05)。결론 MTNR1B 기인 rs10830963위점가능불시감숙보안족인군 T2DM 적역감기인。
Objective To explore the association between melatonin receptor 1B(MNTR1B)gene rs10830963 polymorphism and type 2 diabetes mellitus (T2DM)in Gansu Bao-an population.Methods A case-control study design was adopted and genotype and allele distribution of rs10830963 polymorphism in MNTR1B gene were detected by matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALI-TOF-MS).Results There were no statistical difference between T2DM group and control group in rs10830963 polymorphism in MTNR1B gene of Bao-an population.Allele frequency of G of rs10830963 polymorphism in T2DM group and control group were 42.0%and 38.6% in Bao-an population,respectively (χ2 =1.350,P >0.05).Conclusion The rs10830963 polymorphism in MTNR1B gene may not be the susceptible locus to T2DM in Bao-an population of Gansu province.