CAJ | 학술논문

目的：观察CD151、MT1-MMP在食管胃交界部腺癌中的表达，探讨它们与该肿瘤侵袭、转移的关系。方法应用免疫组化法检测15例正常黏膜组织、40例异型增生黏膜组织和172例食管胃交界部腺癌组织中CD151、MT1-MMP的表达。结果CD151和MT1-MMP在正常黏膜组织、异型增生黏膜组织和癌组织中的阳性率分别为6．67%、20．0%、78．3%和13．3%、22．5%、79．1%，二者在正常胃组织、异型增生胃黏膜组织和癌组织中的表达均逐渐增高，差异均有显著性( P <0．05)。CD151、MT1-MMP在分化程度低、侵及浆膜层以及有淋巴结转移的食管胃交界部腺癌中的表达均明显高于分化程度高、未侵及浆膜层以及无淋巴结转移组(P<0．05)。 CD151与MT1-MMP在食管胃交界部腺癌中的表达呈正相关(P<0．05)。结论CD151和MT1-MMP在食管胃交界部腺癌中均呈高表达，且CD151和MT1-MMP的表达呈正相关，二者可能起协同作用，共同参与食管胃交界部腺癌的侵袭和转移。
목적：관찰CD151、MT1-MMP재식관위교계부선암중적표체，탐토타문여해종류침습、전이적관계。방법응용면역조화법검측15례정상점막조직、40례이형증생점막조직화172례식관위교계부선암조직중CD151、MT1-MMP적표체。결과CD151화MT1-MMP재정상점막조직、이형증생점막조직화암조직중적양성솔분별위6．67%、20．0%、78．3%화13．3%、22．5%、79．1%，이자재정상위조직、이형증생위점막조직화암조직중적표체균축점증고，차이균유현저성( P <0．05)。CD151、MT1-MMP재분화정도저、침급장막층이급유림파결전이적식관위교계부선암중적표체균명현고우분화정도고、미침급장막층이급무림파결전이조(P<0．05)。 CD151여MT1-MMP재식관위교계부선암중적표체정정상관(P<0．05)。결론CD151화MT1-MMP재식관위교계부선암중균정고표체，차CD151화MT1-MMP적표체정정상관，이자가능기협동작용，공동삼여식관위교계부선암적침습화전이。
Purpose To investigate the expression of the protein of CD151 and MT1-MMP in adenocarcinoma of esophagogastric junc-tion tissues and to explore their relationship with the invasiveness and metastasis of the tumor. Methods CD151 and MT1-MMP pro-tein were detected by immunohistochemical staining respectively in 15 cases of paraneoplastic normal gastric mucosa tissue, 40 cases dysplasia and 172 cases of adenocarcinoma of esophagogastric junction tissues. Results All of the expression level of CD151 and MT1-MMP protein were increasing according to the order of normal-dysplsia-carcinoma. The expression rate of CD151 was 6. 67%, 20. 0% and 78. 3%, while the rate of MT1-MMP with 13. 3%, 22. 5% and 79. 1% in the normal, dysplasia and carcinoma subgroup. The expression rate of each protein were significant difference among the three goroups (P<0. 05). In the adenocarcinoma of esopha-gogastric junction tissues, the expression of them in the subgroup of poorly-differentiated with serosa invasion and lymph nodes metasta-sis was significantly higher than the other subgroup of well-differentiated with non serosa invasion or lymph nodes metastasis ( P <0. 05 ) . There was a positive correlation between the expression of CD151 and MT1-MMP protein in adenocarcinoma of esophagogastric junction tissues ( P<0. 05 ) . Conclusions CD151 and MT1-MMP assuredly and highly express in the adenocarcinoma of esopha-gogastric junction tissues and they have close relationships, which could involved in the invasiveness and metastasis synergistically in this tumor.