CAJ | 학술논문

目的：观察HNF-1β在卵巢不同类型上皮性癌中的表达,探讨HNF-1β在卵巢透明细胞癌诊断中的价值。方法采用免疫组化EnVision法检测27例透明细胞癌、35例高级别浆液性癌、21例子宫内膜样腺癌、10例黏液性癌、2例移行细胞癌和13例转移性Krukenberg瘤中HNF-1β的表达。结果27例卵巢透明细胞癌均不同程度表达HNF-1β,阳性率为85．2%；35例卵巢高级别浆液性癌中HNF-1β呈核阳性者4例,阳性率为2．9%；21例卵巢子宫内膜样腺癌中5例HNF-1β呈阳性,阳性率为23．8%；10例卵巢黏液性癌中HNF-1β均呈核阳性,阳性率为60．0%；13例Krukenberg瘤均可见HNF-1β呈不同程度核阳性,阳性率为53．8%；2例卵巢移行细胞癌均不表达HNF-1β。与透明细胞癌相比,HNF-1β在浆液性癌和子宫内膜样腺癌中的表达降低,差异有统计学意义( P<0．01)。黏液性癌、Krukenberg瘤和透明细胞癌中HNF-1β表达差异均无显著性( P>0．05)。 HNF-1β诊断卵巢透明细胞癌的敏感性和特异性分别为85．2%和76．5%。结论 HNF-1β是一种敏感性较高的卵巢透明细胞癌标志物,HNF-1β弥漫强阳性对诊断卵巢透明细胞癌具有较高的特异性。
목적：관찰HNF-1β재란소불동류형상피성암중적표체,탐토HNF-1β재란소투명세포암진단중적개치。방법채용면역조화EnVision법검측27례투명세포암、35례고급별장액성암、21례자궁내막양선암、10례점액성암、2례이행세포암화13례전이성Krukenberg류중HNF-1β적표체。결과27례란소투명세포암균불동정도표체HNF-1β,양성솔위85．2%；35례란소고급별장액성암중HNF-1β정핵양성자4례,양성솔위2．9%；21례란소자궁내막양선암중5례HNF-1β정양성,양성솔위23．8%；10례란소점액성암중HNF-1β균정핵양성,양성솔위60．0%；13례Krukenberg류균가견HNF-1β정불동정도핵양성,양성솔위53．8%；2례란소이행세포암균불표체HNF-1β。여투명세포암상비,HNF-1β재장액성암화자궁내막양선암중적표체강저,차이유통계학의의( P<0．01)。점액성암、Krukenberg류화투명세포암중HNF-1β표체차이균무현저성( P>0．05)。 HNF-1β진단란소투명세포암적민감성화특이성분별위85．2%화76．5%。결론 HNF-1β시일충민감성교고적란소투명세포암표지물,HNF-1β미만강양성대진단란소투명세포암구유교고적특이성。
Purpose To study the expression of HNF-1β in different type ovarian carcinoma and to explore the diagnostic value of HNF-1β in the diagnosis of ovarian clear cell carcinoma. Methods Immunohistochemical EnVision method was used to detect the ex-pression of HNF-1βin 27 clear cell carcinomas, 35 high-grade serous carcinomas, 21 endometrioid adenocarcinoma, 10 mucious carci-nomas, 13 metastatic Krukenberg tumors, and 2 transitional carcinomas. Results All of ovarian clear cell carcinomas variably ex-pressed HNF-1β and the positive rate of HNF-1β in ovarian cleat cell carcinoma was 85. 2%. Of 21 ovarian serous carcinomas, the nuclear positive of HNF-1β was 4 and HNF-1βpositive rate was 2. 9%. There was 5 HNF-1βexpression in endometrioid adenocarci-noma and the positive rate of HNF-1β was 23. 8%. The positive rate of HNF-1β in mucious carcinoma and metastatic Krukenberg tumor was 60. 0% and 53. 8%, respectively. No HNF-1βexpression was seen in transtional cell carcinoma. The sensitivity and speci-ficity of HNF-1β in the diagnosis of ovarian clear cell carcinoma was 85. 2% and 76. 5%. Conclusions HNF-1β may be a higher sensitive marker for the diagnosis of ovarian clear cell carcinoma. The diffuse and strong positive of HNF-1βmay have higher specific for diagnosis of ovarian clear cell carcinoma.